|
Craniosynostosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specific T2R38 polymorphisms, correlating with bitter taste sensitivity to phenylthiocarbamide (PTC), have been identified as an independent risk factor for surgical intervention in CRS patients without polyps; however, the exact role of PTC tasting ability in clinical practice remains unknown.
|
29972727 |
2018 |
|
Craniosynostosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among the predisposing factors implicated in the immune response to airway bacterial infections, genetic variations of the bitter taste receptor TAS2R38, which is expressed in the cilia of the human sinonasal epithelial cells, seem to be associated with susceptibility to chronic rhinosinusitis (CRS) and in vitro biofilm formation.
|
29570813 |
2018 |
|
Craniosynostosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bitter (T2R) and sweet (T1R) taste receptors in the airway are important in innate immune defense, and variations in taste receptor functionality in one T2R (T2R38) correlate with disease status and disease severity in chronic rhinosinusitis (CRS).
|
29643854 |
2018 |
|
Craniosynostosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in T2R38 functionality has been shown to be associated with susceptibility to upper respiratory tract infections and chronic rhinosinusitis (CRS).
|
28214914 |
2017 |
|
Craniosynostosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The T2R38 gene has been shown to be applicable in the clinical setting with a testable phenotype and may have a role in the prognosis and influencing management strategies of CRS patients.
|
27841768 |
2017 |
|
Craniosynostosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The bitter taste receptor T2R38 has been shown to play a role in the pathogenesis of chronic rhinosinusitis (CRS), where the receptor functions to enhance upper respiratory innate immunity through a triad of beneficial immune responses.
|
28218655 |
2017 |
|
Craniosynostosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The formation of mature cilia is necessary for T2R38 expression and function, and polymorphisms that underlie T2R38 functionality appear to be involved in susceptibility to upper respiratory infection and recalcitrant CRS.
|
27650657 |
2017 |
|
Craniosynostosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found between TAS2R38 alleles or genotypes and CRS, thus questioning its role in the pathogenesis of CRS.
|
27515546 |
2016 |
|
Craniosynostosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study is to investigate the significance of T2R38 genotype in the variability of sinonasal QOL and CRS disease severity in a sample of CF patients.
|
26678226 |
2016 |
|
Craniosynostosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our goal was to determine whether TAS2R38 genetics predicts outcomes in CRS patients following sinus surgery.
|
26562612 |
2016 |
|
Craniosynostosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study replicates previous work which showed that the coding SNP rs10246939 in the TAS2R38 gene is associated with CRS.
|
24415641 |
2014 |
|
Craniosynostosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to determine whether the nonprotective TAS2R38 polymorphisms, which render the receptor inactive, correlate with medically recalcitrant chronic rhinosinusitis (CRS) necessitating surgical intervention in the context of known risk factors, and thus identify whether the TAS2R38 genotype is an independent risk factor for patients undergoing functional endoscopic sinus surgery (FESS).
|
24302675 |
2014 |
|
Craniosynostosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A literature review was performed of the current knowledge of the bitter taste receptor T2R38 in sinonasal physiology and CRS patient outcomes.
|
23883809 |
2013 |