PTCH1, patched 1, 5727

N. diseases: 604; N. variants: 194
Disease: Trisomy 12 ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0432408
Disease: Trisomy 12
Trisomy 12 		0.010 AlteredExpression phenotype BEFREE Our results demonstrate that the HH-signaling pathway is an interesting therapeutic target for a subset of patients with CLL, characterized by high GLI1 and PTCH1 transcript levels, and all patients with trisomy 12 and indicate HH-blocking Abs to be favorable over SMO inhibitors in overcoming stroma-mediated protective effects. 22130798 2012