PTEN was significantly lost in both endometriosis and invasive tumour tissues, while oestrogen receptor (ER) expression was lost in OCCC relative to endometriosis.
Co-occurrence of this pathogenic germline mutation in <i>PTEN</i> in this patient, early development of OCCC at age 28 years, and total loss of PTEN expression in the tumor might support the involvement of <i>PTEN</i> in the carcinogenesis of her ovarian cancer.
This study aims to evaluate the relationships between chromosome 20q13.2 zinc finger protein 217 (ZNF217) locus amplification, ZNF217 expression, E-cadherin expression, and PI3K-Akt pathway alterations (activating PIK3CA mutations or loss of phosphatase and tensin homolog [PTEN] expression), and whether these molecular alterations can predict the clinical survival data in ovarian clear cell carcinoma (OCCC) patients.