Co-occurrence of this pathogenic germline mutation in <i>PTEN</i> in this patient, early development of OCCC at age 28 years, and total loss of PTEN expression in the tumor might support the involvement of <i>PTEN</i> in the carcinogenesis of her ovarian cancer.
PTEN was significantly lost in both endometriosis and invasive tumour tissues, while oestrogen receptor (ER) expression was lost in OCCC relative to endometriosis.
This study aims to evaluate the relationships between chromosome 20q13.2 zinc finger protein 217 (ZNF217) locus amplification, ZNF217 expression, E-cadherin expression, and PI3K-Akt pathway alterations (activating PIK3CA mutations or loss of phosphatase and tensin homolog [PTEN] expression), and whether these molecular alterations can predict the clinical survival data in ovarian clear cell carcinoma (OCCC) patients.