Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our previous study observed that the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was downregulated in thrombin-stimulated lung cancer.
|
25861627 |
2015 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine the role of the PTEN/MMAC1 gene in lung cancer, we screened 34 small cell lung cancer (SCLC) cell lines, 10 SCLC tumors, 13 non-small cell lung cancer (NSCLC) cell lines and 10 NSCLC tumors using Denaturing HPLC (DHPLC) and direct sequencing methods.
|
9696041 |
1998 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the role of PTEN alternations and its association with outcome variables in the genesis of lung carcinoma are not understood fully.
|
24133589 |
2013 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR.
|
19351834 |
2009 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Implication of a protein-tyrosine-phosphatase in human lung cancer.
|
7981622 |
1994 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer.
|
28662101 |
2017 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Phosphatase and tensin homolog (PTEN) loss has been recently reported as a gefitinib resistance mechanism in lung cancer.
|
23592446 |
2013 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The downregulation of miR21 and miR181b-1 and subsequent activation of PTEN/Akt and CYLD/IκB signaling axis leading to decreased NF-κB activity required to maintain the tumor-inhibiting effect of Rig-G.. Our findings contribute to a better understanding of the antitumor effect mechanism of Rig-G, as well as offer a novel strategy for lung cancer therapy.
|
27602766 |
2016 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In contrast, engineered gain of USP18 expression in these same lung cancer cell lines stabilized PTEN protein.
|
27980214 |
2017 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lack of expression of PTEN is a non-sufficient condition leads to lung cancer formation alone.
|
23261230 |
2013 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy.
|
29378193 |
2018 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that TOPK is a potential therapeutic target in lung cancer that promotes cell migration by modulating a PI3K/PTEN/AKT-dependent signaling pathway; they also suggest that high TOPK expression, either alone or in combination with a low level of PTEN, may serve as a prognostic marker for lung cancer.
|
21996732 |
2012 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, miR-10a targets PTEN to mediate the anti-tumor effect of icaritin in A549 cells, which provides a novel insight into the anti-tumor mechanism of icaritin and may provide a new strategy for lung cancer therapy.
|
31829310 |
2019 |
Carcinoma of lung
|
0.400 |
CausalMutation
|
disease |
CGI |
|
|
|
Carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Decreased AKT phosphorylation (S473) was significantly associated with PTEN mutation under glucose starvation conditions in lung cancer cell lines.
|
26573869 |
2016 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients.
|
17409929 |
2006 |
Carcinoma of lung
|
0.400 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Carcinoma of lung
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
PTEN inactivation in lung cancer cells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors.
|
17912443 |
2007 |
Carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent evidence suggests that downregulation of gene of phosphatase and tensin homolog deleted on chromosome 10 plays an important role in acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in various types of cancers, including lung cancer.
|
28714370 |
2017 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings implicate the miR-23a/PTEN axis as a novel therapeutic target for lung cancer radiotherapy.
|
28852584 |
2017 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggested that SHCBP1 may be upregulated in lung cancer and it may serve a key role in the apoptosis of lung cancer cells; this effect was associated with the expression of PTEN.
|
31423258 |
2019 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that PTEN/MMAC1/TEP1 plays a role as a tumor suppressor gene in the genesis and/or progression of human lung cancer.
|
9598803 |
1998 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer.
|
18728656 |
2008 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles.
|
27823967 |
2016 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
MicroRNA-101 suppresses progression of lung cancer through the PTEN/AKT signaling pathway by targeting DNA methyltransferase 3A.
|
28123563 |
2017 |