Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, miR-10a targets PTEN to mediate the anti-tumor effect of icaritin in A549 cells, which provides a novel insight into the anti-tumor mechanism of icaritin and may provide a new strategy for lung cancer therapy.
|
31829310 |
2019 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggested that SHCBP1 may be upregulated in lung cancer and it may serve a key role in the apoptosis of lung cancer cells; this effect was associated with the expression of PTEN.
|
31423258 |
2019 |
Carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
And, it has been reported that both PTEN loss and NF-κB activation contribute to intrinsic EGFR-TKI resistance in EGFR-mutant lung cancer.
|
31497352 |
2019 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the molecular mechanism of EMT induced by PTEN inactivation is not clear in lung cancer.
|
30885348 |
2019 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation or inhibition of PRMT5 markedly reduced Akt phosphorylation at Thr308 and Ser473, whereas the expression of PTEN and mTOR phosphorylation was unchanged, indicating that PRMT5 was an important upstream regulator of Akt and induced lung cancer cell proliferation.
|
30461193 |
2019 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
The deubiquitylase OTUD3 plays a suppressive role in breast tumorigenesis through stabilizing PTEN protein, but its role in lung cancer remains unclear.
|
31266968 |
2019 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTEN protein loss is a frequent event in lung cancer, but genetic alterations are not equally detected.
|
31404976 |
2019 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy.
|
29378193 |
2018 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
We suggested a tumor suppressor function of USP10 in lung cancer via deubiquitinating and stabilizing PTEN.
|
28852924 |
2018 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consistent with these findings, we observed increased PTEN phosphorylation and reduced nuclear PTEN levels in lung cancer patient samples establishing phosphorylation as a bona fide inactivation mechanism for PTEN in lung cancer.
|
29108454 |
2018 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We identified PTEN as miR-130b's major target and inversely correlated with miR-130b expression in LC.
|
29653464 |
2018 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Negative Regulation of PTEN by MicroRNA-221 and Its Association with Drug Resistance and Cellular Senescence in Lung Cancer Cells.
|
29876362 |
2018 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) negatively regulates phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein levels through polyubiquitination and proteolysis, but its significance in lung cancer is still unclear.
|
29271375 |
2018 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer.
|
28662101 |
2017 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In contrast, engineered gain of USP18 expression in these same lung cancer cell lines stabilized PTEN protein.
|
27980214 |
2017 |
Carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recent evidence suggests that downregulation of gene of phosphatase and tensin homolog deleted on chromosome 10 plays an important role in acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in various types of cancers, including lung cancer.
|
28714370 |
2017 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings implicate the miR-23a/PTEN axis as a novel therapeutic target for lung cancer radiotherapy.
|
28852584 |
2017 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
MicroRNA-101 suppresses progression of lung cancer through the PTEN/AKT signaling pathway by targeting DNA methyltransferase 3A.
|
28123563 |
2017 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The downregulation of miR21 and miR181b-1 and subsequent activation of PTEN/Akt and CYLD/IκB signaling axis leading to decreased NF-κB activity required to maintain the tumor-inhibiting effect of Rig-G.. Our findings contribute to a better understanding of the antitumor effect mechanism of Rig-G, as well as offer a novel strategy for lung cancer therapy.
|
27602766 |
2016 |
Carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Decreased AKT phosphorylation (S473) was significantly associated with PTEN mutation under glucose starvation conditions in lung cancer cell lines.
|
26573869 |
2016 |
Carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Multiple primary lung cancer displaying different EGFR and PTEN molecular profiles.
|
27823967 |
2016 |
Carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have developed a Drosophila lung cancer model by targeting Ras1(G12V)--alone or in combination with PTEN knockdown--to the Drosophila tracheal system.
|
26832408 |
2016 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The presence of PTEN expression may define a subset of patients with lung cancer appropriate for investigational therapeutic strategies.
|
27333149 |
2016 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our previous study observed that the expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was downregulated in thrombin-stimulated lung cancer.
|
25861627 |
2015 |
Carcinoma of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
And then, we found there is a negative relationship between the expression of miR-205 and PTEN mRNA in lung cancer by analyzed.
|
25973003 |
2015 |