PTEN, phosphatase and tensin homolog, 5728

N. diseases: 1349; N. variants: 384
Disease: Fatty Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.520 Biomarker disease BEFREE PTEN negatively regulates the enzymes involved in hepatic gluconeogenesis and lipid synthesis, which suggests that PTEN may be a therapeutic target for ketosis and fatty liver in dairy cows. 30819264 2019
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.520 Biomarker disease CTD_human Toll-like Receptor 4 on Macrophage Promotes the Development of Steatohepatitis-related Hepatocellular Carcinoma in Mice. 27022031 2016
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.520 AlteredExpression disease BEFREE In conclusion, OA activates GPR40-PLC-calcium pathway to increase the expression of PPARδ and PPARδ further decreased the expression of PTEN to regulate insulin sensitivity in hepatic steatosis. 22209682 2012
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.520 Biomarker disease RGD PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism. 18166358 2008
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.520 Biomarker disease MGD