PTEN, phosphatase and tensin homolog, 5728

N. diseases: 1349; N. variants: 384
Disease: Acoustic Neuroma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027859
Disease: Acoustic Neuroma
Acoustic Neuroma 		0.020 Biomarker disease BEFREE Because PTEN regulates signaling through the growth-promoting phosphoinositide 3-kinase/AKT pathway, our findings suggest that miR-21 may be a suitable molecular target for therapies aimed specifically at reducing VS growth. 20856158 2010
CUI: C0027859
Disease: Acoustic Neuroma
Acoustic Neuroma 		0.020 GeneticVariation disease BEFREE The maintained expression of the PTEN protein, together with the lack of detectable mutations in this gene, suggests that the function of the PTEN tumour suppressor gene is not altered in sporadic vestibular schwannomas. 12047763 2002