|
Toxic Epidermal Necrolysis
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
In a previous genome-wide association study of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) patients we reported the association between SJS/TEN and the prostaglandin E receptor 3 (PTGER3) gene, and that its protein PGE<sub>2</sub> receptor 3 (EP3) was markedly downregulated in the conjunctival epithelium of SJS/TEN patients.
|
31000507 |
2019 |
|
Toxic Epidermal Necrolysis
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphism association analysis showed that the Toll-like receptor 3 (TLR3), prostaglandin-E receptor 3 (PTGER3), and IKZF1 gene were significantly associated with CM-SJS/TEN with SOC and that they could regulate mucocutaneous inflammation including that of the ocular surface.
|
30481825 |
2018 |
|
Toxic Epidermal Necrolysis
|
0.320 |
Biomarker
|
disease |
CTD_human |
In the current study we investigated the expression of EP3 protein in the conjunctiva of patients with various ocular surface diseases such as SJS/TEN, chemical eye burns, Mooren's ulcers, and ocular cicatricial pemphigoid (OCP).
|
21966456 |
2011 |
|
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
In a previous genome-wide association study of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) patients we reported the association between SJS/TEN and the prostaglandin E receptor 3 (PTGER3) gene, and that its protein PGE<sub>2</sub> receptor 3 (EP3) was markedly downregulated in the conjunctival epithelium of SJS/TEN patients.
|
31000507 |
2019 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
We found that levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased, and levels of prostaglandin-endoperoxide synthase 2 (PTGS2; aka COX-2) mRNA are decreased, in older subjects with schizophrenia (> 40years of age) compared to matched normal controls or younger subjects with schizophrenia (< 40years of age).
|
22397921 |
2012 |
|
Schizophrenia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We found that levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased, and levels of prostaglandin-endoperoxide synthase 2 (PTGS2; aka COX-2) mRNA are decreased, in older subjects with schizophrenia (> 40years of age) compared to matched normal controls or younger subjects with schizophrenia (< 40years of age).
|
22397921 |
2012 |
|
Stevens-Johnson Syndrome
|
0.310 |
Biomarker
|
disease |
CTD_human |
In our earlier genome-wide association study on Stevens-Johnson Syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), we found that in Japanese patients with these severe ocular surface complications there was an association with prostaglandin E receptor 3 (EP3) gene (PTGER3) polymorphisms.
|
21966456 |
2011 |
|
Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum
|
0.310 |
Biomarker
|
disease |
CTD_human |
Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders.
|
21966456 |
2011 |
|
Stevens-Johnson Syndrome
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study.
|
20947153 |
2010 |
|
Pemphigoid, Benign Mucous Membrane
|
0.300 |
Biomarker
|
disease |
CTD_human |
Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders.
|
21966456 |
2011 |
|
Polycystic Ovary Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
|
21411543 |
2011 |
|
Sclerocystic Ovaries
|
0.300 |
Biomarker
|
disease |
CTD_human |
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles.
|
21411543 |
2011 |
|
Drug-Induced Stevens Johnson Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders.
|
21966456 |
2011 |
|
Ocular Cicatricial Pemphigoid
|
0.300 |
Biomarker
|
disease |
CTD_human |
In the current study we investigated the expression of EP3 protein in the conjunctiva of patients with various ocular surface diseases such as SJS/TEN, chemical eye burns, Mooren's ulcers, and ocular cicatricial pemphigoid (OCP).
|
21966456 |
2011 |
|
Mycoplasma-Induced Stevens-Johnson Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders.
|
21966456 |
2011 |
|
Drug Allergy
|
0.300 |
Biomarker
|
group |
CTD_human |
Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics.
|
20587336 |
2010 |
|
Thrombosis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors.
|
17242161 |
2007 |
|
Thrombus
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors.
|
17242161 |
2007 |
|
Asthma
|
0.230 |
Therapeutic
|
disease |
RGD |
Adenosine A(1) and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury.
|
23221044 |
2013 |
|
Asthma
|
0.230 |
GeneticVariation
|
disease |
BEFREE |
Our findings provide further evidence that polymorphisms in PTGER3 might play a significant role in aspirin hypersensitivity among Korean asthmatics.
|
20587336 |
2010 |
|
Asthma
|
0.230 |
GeneticVariation
|
disease |
LHGDN |
Association between genetic variations in prostaglandin E2 receptor subtype EP3 gene (Ptger3) and asthma in the Korean population.
|
17877755 |
2007 |
|
Asthma
|
0.230 |
GeneticVariation
|
disease |
BEFREE |
Through association analyses studies of the 32 single nucleotide polymorphisms, the following single nucleotide polymorphisms were found to have significant associations with the aspirin-intolerant asthma phenotype: -616C>G (P=0.038) and -166G>A (P=0.023) in PTGER2; -1709T>A (P=0.043) in PTGER3; -1254A>G (P=0.018) in PTGER4; 1915T>C (P=0.015) in PTGIR; and -4684C>T (P=0.027), and 795T>C (P=0.032) in TBXA2R.
|
17496729 |
2007 |
|
Malignant tumor of colon
|
0.210 |
Biomarker
|
disease |
BEFREE |
In the present study, human colon cancer HCA-7 cells were used as a model system to understand the potential role of EP3 receptors in tumor cell migration.
|
21070749 |
2011 |
|
Malignant tumor of colon
|
0.210 |
Biomarker
|
disease |
RGD |
Effects of EP(3) receptor activation on cell growth of human colon cancer cell lines were examined using ONO-AE-248, an EP(3) selective agonist.
|
15247185 |
2004 |
|
Hyperalgesia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation.
|
17413918 |
2007 |