|
Breast Carcinoma
|
0.130 |
Biomarker
|
disease |
BEFREE |
circ_0005230/miR-618/CBX8 axis might play a key role in BC tumorigenesis and development.
|
30504704 |
2018 |
|
Breast Carcinoma
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Breast Carcinoma
|
0.130 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, Cbx8 is overexpressed in human breast cancer and correlates with poor survival.
|
27346354 |
2016 |
|
Breast Carcinoma
|
0.130 |
Biomarker
|
disease |
BEFREE |
To better understand the DeltaNp73-mediated transactivation of the BTG2TIS21/PC3 gene we performed luciferase assays with two reporter plasmids harboring long and short BTG2 promoter sequences in three human neuroblastoma cell lines and one breast cancer cell line.
|
15741235 |
2005 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
CBX8 promotes tumorigenesis and confers radioresistance in esophageal squamous cell carcinoma cells through targeting APAF1.
|
31255735 |
2019 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
circ_0005230/miR-618/CBX8 axis might play a key role in BC tumorigenesis and development.
|
30504704 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Chromobox homolog 8 (CBX8), also known as human polycomb 8, is a repressor that maintains the transcriptionally repressive state in various cellular genes, and has been reported to promote tumorigenesis.
|
28837252 |
2017 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Although CBX8 has been reported to promote the esophageal squamous cell carcinoma (ESCC) tumorigenesis, its role in ESCC metastasis has not been explored yet.
|
28912889 |
2017 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Thus, our study implicates a key non-canonical role for Cbx8 in promoting breast tumorigenesis.
|
27346354 |
2016 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
CBX8, a novel DNA repair protein, promotes tumorigenesis in human esophageal carcinoma.
|
25197352 |
2014 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
BMP4 expression reverses the effects of CBX8 silencing in inhibiting epithelial-mesenchymal transition, stemness, and metastasis.
|
30718464 |
2019 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Ectopic expression of CBX8 facilitated tumor growth and metastasis, whereas CBX8 silencing suppressed these effects.
|
29066512 |
2018 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Collectively, CBX8 may play paradoxical roles in ESCC, inhibiting metastasis while promoting cell proliferation.
|
28912889 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
However, knockdown of CBX8 enhanced CRC migration, invasion and metastasis in vitro and in vivo, in part through direct up-regulation of integrin β4 (ITGB4) that in turn decreased RhoA activity.
|
25360999 |
2014 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
In the highly metastatic cancer cell PC3, gene silencing of TLR4 using siRNA significantly inhibited TLR4 mRNA expression and protein level.
|
19643479 |
2009 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
The luciferase reporter assay was used to determine the direct regulation of miR-518d-5p/519-5p and circRNA8924 or CBX8 Results: The study demonstrated that the expression level of circRNA8924 in CC was significantly higher than that in the adjacent normal tissues (P < 0.001), and that it was also associated with tumor size, FIGO staging and myometrial invasion.
|
30007986 |
2018 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Ectopic expression of CBX8 facilitated tumor growth and metastasis, whereas CBX8 silencing suppressed these effects.
|
29066512 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
In vivo, tumor (PC-3) targeting for [<sup>68</sup>Ga]3 and [<sup>68</sup>Ga]4 increased over time, with dynamic μPET showing clearer tumors images at later time points.
|
29432691 |
2018 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Collectively, CBX8 might emerge as an oncogene for promoting the proliferation of tumor cells and raising the resistance of neoplasms to chemotherapy.
|
25197352 |
2014 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Aberrant expression of CBX8 has been identified in many types of cancer, but the cause of this aberrant CBX8 expression and whether CBX8 is associated with stemness properties in CC remain unknown.
|
31849331 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our results provide novel insight into CBX8 as a therapeutic target to improve the radiosensitivity of ESCC.
|
31255735 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Aberrant expression of CBX8 has been identified in many types of cancer, but the cause of this aberrant CBX8 expression and whether CBX8 is associated with stemness properties in CC remain unknown.
|
31849331 |
2019 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
CBX8 was upregulated in HCC and its expression correlated with cell cycle progression.
|
31495785 |
2019 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings have implications for the targeting of CBX8 as an approach to HCC prognosis and treatment.
|
30718464 |
2019 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
circ_0005230/miR-618/CBX8 axis might play a key role in BC tumorigenesis and development.
|
30504704 |
2018 |