|
Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of these genes enhances viral replication and induces germinal center (GC) B cell expansion, activation-induced cytidine deaminase (AID) expression, and c-myc translocation, which in turn predisposes to BL.
|
28707393 |
2017 |
|
Burkitt Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo, this could be sufficient to account for the elevated risk of BL-specific chromosomal translocations which would occur following DNA double strand breaks triggered by AID in secondary lymph nodes at the final stage of immunoglobulin gene maturation.
|
28360415 |
2017 |
|
Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High levels of AID cause strand bias of mutations at A versus T in Burkitt's lymphoma cells.
|
23399385 |
2013 |
|
Burkitt Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IgH partner breakpoint sequences provide evidence that AID initiates t(11;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas.
|
22915650 |
2012 |
|
Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This is classically illustrated in Burkitt's lymphoma, which is characterized by AID-induced mutation and reciprocal translocation of the c-MYC oncogene with the IgH loci.
|
21831295 |
2011 |
|
Burkitt Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Transcription of the switch (S) regions of immunoglobulin genes in B cells generates stable R-loops that are targeted by Activation Induced Cytidine Deaminase (AID), triggering class switch recombination (CSR), as well as translocations with c-MYC responsible for Burkitt's lymphomas.
|
21383964 |
2011 |
|
Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD40 ligand incorporated into the HIV envelope and expression of activation-induced cytidine deaminase may help explain the relationship between HIV load and Burkitt lymphoma.
|
20978397 |
2010 |
|
Burkitt Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that Burkitt lymphoma cell lines may be deficient in an unidentified factor that recruits the machinery necessary for A:T mutation or that AID-mediated cytosine deamination in these cells may be processed by conventional base excision repair truncating somatic hypermutation at the G:C phase.
|
17240451 |
2007 |
|
Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Additionally, AID expression was seen to differ depending on NHL subtype, with the highest levels of expression seen in those who developed Burkitt's lymphoma.
|
18090274 |
2007 |
|
Burkitt Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This observation verifies that overexpression of AID in non hypermutating BL cell lines as well as the expression of endogenous AID in the hypermutating BL cell line Raji can overcome the target restriction of AID.
|
16310251 |
2006 |
|
Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As expected, AID overexpression in the human Burkitt lymphoma cell line BL70 caused hypermutation.
|
15593119 |
2005 |
|
Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated the expression of AID in 15 BL cell lines by RT-PCR.
|
15061213 |
2004 |
|
Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In only 2 BL cell lines, Tree92 and Black93, AID expression was not detected, and the 1gVH gene of these 2 cell lines was not mutated.
|
15061213 |
2004 |
|
Burkitt Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using 2 specific antibodies, here we show that the AID protein can be detected in GC centroblasts and their transformed counterpart (Burkitt lymphoma) but not in pre-GC B cells and post-GC neoplasms, including B-cell chronic lymphocytic leukemia and multiple myeloma.
|
15304391 |
2004 |
|
Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, half of Burkitt lymphomas tested were found to express AID, at most at levels comparable with those found in normal GC B cells.
|
12873980 |
2003 |
|
Burkitt Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A chromosomal translocation (Tx) that interrupts the transcription of either c-Myc or Pvt 1 is the principal lesion in many B cell malignancies including Burkitt's Lymphoma (BL), AIDs-NHL, mouse plasmacytoma (Pct) and possibly multiple myeloma (MM).
|
9308229 |
1997 |