The estimated polygenic variance was reduced by 30% to 50% after allowing for unidentified major genes and decreased from 3.3 for age <40 years to 0.5 for age ≥70 years (equivalent to sibling relative risks of 5.1 to 1.3, respectively).<b>Conclusions:</b> Unidentified major genes might explain one third to one half of the missing heritability of colorectal cancer.<b>Impact:</b> Our findings could aid gene discovery and development of better colorectal cancer risk prediction models.
Immunohistochemistry revealed the enhanced expression of endogenous AID protein in not only in the inflamed colonic mucosa of ulcerative colitis patients but also CAC tumor lesions.