|
Chronic Lymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Impact and Prognostic Significance of Chronic Lymphocytic Leukemia Upregulated 1 (CLLU1) Gene Expression in Patients with Chronic Lymphocytic Leukemia: A Single Center Experience.
|
31589746 |
2019 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CLLU1 expression analysis helps to refine the prognosis of patients with chronic lymphocytic leukemia who have mutated IGHV genes.
|
22899580 |
2013 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms.
|
22738889 |
2012 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression levels of LPL, ZAP70, TCL1A, CLLU1 and MCL1 have recently been proposed as prognostic factors in chronic lymphocytic leukemia.
|
21508119 |
2011 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined whether the CLLU1 real-time quantitative PCR (RQ-PCR) could detect small numbers of CLL cells in mixtures of normal peripheral blood mononuclear (PBMC) cells.
|
21323738 |
2011 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene profiling studies on chronic lymphocytic leukaemia (CLL) are at the origin of new prognosis markers such as zeta-associated protein-70 (ZAP-70), LPL and CLLU1, which, at present, are under study for their application to clinical practice.
|
19698929 |
2009 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
LHGDN |
Thus, analysis of CLLU1 expression is highly applicable in risk prediction in CLL for patients of an age eligible for risk stratification.
|
17284524 |
2007 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To investigate CLLU1 expression in CLL and explore the relationship between CLLU1 expression and alternative prognostic markers, we measured CLLU1 expression levels by semiquantitative RT-PCR in a cohort of 50 Chinese patients with CLL.
|
17786715 |
2007 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data, in particular the unique and restricted expression pattern, suggest that CLLU1 is the first disease-specific gene identified in CLL.
|
16339396 |
2006 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patient stratification according to clinical stage, cytogenetics, IgV(H) mutational status, ZAP-70 and CD38, demonstrated significantly increased CLLU1 expression in all investigated CLL poor risk groups.
|
16529606 |
2006 |
|
Chronic Lymphocytic Leukemia
|
0.100 |
Biomarker
|
disease |
LHGDN |
These data, in particular the unique and restricted expression pattern, suggest that CLLU1 is the first disease-specific gene identified in CLL.
|
16339396 |
2006 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Analysis of CLLU1 expression is a rapid and reliable tool that may facilitate the diagnosis of mature B-cell neoplasms especially in inconclusive cases.
|
22738889 |
2012 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Assessment of blood CLLU1 levels can be used as a reliable marker of tumor burden and has the potential to complement currently used techniques for MRD monitoring in patients with CLL.
|
21323738 |
2011 |
|
Neoplasm, Residual
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Assessment of blood CLLU1 levels can be used as a reliable marker of tumor burden and has the potential to complement currently used techniques for MRD monitoring in patients with CLL.
|
21323738 |
2011 |
|
Hematologic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
However, appreciable levels of CLLU1 were detectable only in CLL cells and not in a panel of normal tissue extracts or in any other tested hematologic malignancy.
|
16339396 |
2006 |
|
Trisomy 12
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
High expression of CLLU1 in CLL samples occurred irrespective of trisomy 12 or large chromosomal rearrangements.
|
16339396 |
2006 |