|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The vitamin D receptor gene (VDR) is a compelling candidate tumor suppressor gene for parathyroid adenomas based on existing evidence of the vitamin D system's antiproliferative actions in parathyroid and other tissues, its reported inhibition of PTH gene transcription, and the decreased expression of VDR mRNA and VDR protein observed in parathyroid adenomas.
|
17003089 |
2006 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differences in Tc-MIBI DPS, serum parathyroid hormone (PTH), serum calcium and phosphorus, as well as the weight and longest diameter of lesion between PA and PH were also compared.
|
30239472 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
THE RESULTS OF PARATHYROID HORMONE ASSAY IN PARATHYROID ASPIRATES IN PRE-OPERATIVE LOCALIZATION OF PARATHYROID ADENOMAS FOR FOCUSED PARATHYROIDECTOMY IN PATIENTS WITH NEGATIVE OR SUSPICIOUS TECHNETIUM-99M-SESTAMIBI SCANS.
|
28683236 |
2017 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primary hyperparathyroidism (pHPT) is characterized by excessive production of parathyroid hormone (PTH) due to parathyroid adenomas while uremic secondary HPT (sHPT) is caused by parathyroid hyperplasia in response to renal failure.
|
12444900 |
2002 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Diagnostic accuracy of parathyroid hormone levels in washout samples of suspicious parathyroid adenomas: A single-centre retrospective cohort study.
|
30004132 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, on Northern blot analysis, there was a PTH messenger ribonucleic acid transcript with a size similar to that found in parathyroid adenoma or hyperplasia.
|
8077382 |
1994 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
According to these results, parathormone synthesis is high when the proliferative activity of parathyroid adenoma is high.
|
11846729 |
2001 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The main outcome measures were serum total calcium, ionized calcium, intact parathyroid hormone (PTH), albumin, alkaline phosphatase, phosphate, 25-hydroxy vitamin D, 1,25-dihydroxy vitamin D, 24-h urinary calcium levels, and parathyroid adenoma weight.
|
30289305 |
2019 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In case two, the high level of parathyroid hormone (PTH) and the scintigraphy scan showing parathyroid gland adenoma confirmed primary hyperparathyroidism-induced hypercalcemia.
|
29951343 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations: BNE</b> = bilateral neck exploration; <b>CT</b> = computed tomography; <b>IOPTH</b> = intra-operative parathyroid hormone; <b>MGD</b> = multi-gland disease; <b>MIBI</b> = sestamibi; <b>MIP</b> = minimally invasive parathyroidectomy; <b>MRI</b> = magnetic resonance imaging; <b>PHPT</b> = primary hyperparathyroidism; <b>PTA</b> = parathyroid adenoma; <b>PTH</b> = parathyroid hormone; <b>SGA</b> = single-gland adenoma; <b>SPECT</b> = single photon emission computed tomography; <b>4D</b> = four-dimensional.
|
30720353 |
2019 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of chronic elevation of PTH was evaluated in 20 patients affected by PHP at diagnosis and after surgical removal of parathyroid adenoma.
|
26068297 |
2015 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with cystic parathyroid adenomas had higher serum intact parathyroid hormone and calcium levels, larger maximum tumor diameter, and lower serum inorganic phosphorus level than did those with solid adenomas.
|
30123260 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is speculated that allelic loss of the MEN1 suppressor gene and overexpression of cyclin D1 induced by rearrangement of the parathyroid hormone gene may be the major genetic abnormality in sporadic parathyroid adenoma but not in 2-HPT.
|
10048455 |
1999 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is caused by autonomic oversecretion of parathyroid hormone (PTH) owing to parathyroid adenoma, hyperplasia, or tumor.
|
30383698 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It is concluded that the lowered levels of CaR mRNA in parathyroid adenomas may contribute to the increased set point of PTH secretion.
|
9329389 |
1997 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To validate the accuracy of intraoperative measurements of parathyroid hormone levels in parathyroid adenomas.
|
29235733 |
2017 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High PTH levels, 103 (8-78) pg/ml, suggested presence of a parathyroid adenoma.
|
14699620 |
2004 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The VDR genotypes were unrelated to VDR and PTH messenger ribonucleic acid levels in the parathyroid adenomas of 42 PHPT patients.
|
10323401 |
1999 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the demonstration of LOH at 11q13 and MEN1 gene mutations in small parathyroid adenomas of patients with slight hypercalcemia and normal serum PTH levels suggest that altered MEN1 gene function may also be important for the development of mild sporadic pHPT.
|
9709976 |
1998 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
[<sup>18</sup>F]Fluorocholine Uptake of Parathyroid Adenoma Is Correlated with Parathyroid Hormone Level.
|
29508264 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PRAD1, previously designated D11S287E, was identified on 11q13 as a chromosomal breakpoint region rearranged with the parathyroid hormone gene in a subset of parathyroid adenomas; this highly conserved putative oncogene, which encodes a novel cyclin, has been linked to BCL1 and implicated also in subsets of breast and squamous cell neoplasms with 11q13 amplification.
|
1682919 |
1991 |
|
Parathyroid Adenoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of the study was to determine: 1) Klotho expression in parathyroid adenomas from patients with primary hyperparathyroidism (pHPT) compared to normal tissue; and 2) its relation to the serum calcium and PTH levels.
|
18682507 |
2008 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A subset of parathyroid adenomas contains a clonal rearrangement that places the PTH gene's regulatory sequences in proximity to the cyclin D1 Oncogene causing its overexpression, and 20-40% of parathyroid adenomas overexpress the cyclin D1 protein.
|
10704427 |
2000 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Forty-one parathyroid adenomas from patients with symptomatic PHPT and ten normal parathyroid glands either from patients with PHPT (n=3) or from euthyroid patients without PHPT during thyroid surgery (n=7) were analyzed for vitamin D receptor (VDR), calcium-sensing receptor (CASR), cyclin D1 (CD1), and parathyroid hormone (PTH) expressions.
|
23660642 |
2013 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Southern blot analyses of the parathyroid adenoma revealed rearrangement in the PTH gene locus.
|
20641034 |
2010 |