|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is speculated that allelic loss of the MEN1 suppressor gene and overexpression of cyclin D1 induced by rearrangement of the parathyroid hormone gene may be the major genetic abnormality in sporadic parathyroid adenoma but not in 2-HPT.
|
10048455 |
1999 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is caused by autonomic oversecretion of parathyroid hormone (PTH) owing to parathyroid adenoma, hyperplasia, or tumor.
|
30383698 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PRAD1, previously designated D11S287E, was identified on 11q13 as a chromosomal breakpoint region rearranged with the parathyroid hormone gene in a subset of parathyroid adenomas; this highly conserved putative oncogene, which encodes a novel cyclin, has been linked to BCL1 and implicated also in subsets of breast and squamous cell neoplasms with 11q13 amplification.
|
1682919 |
1991 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Southern blot analyses of the parathyroid adenoma revealed rearrangement in the PTH gene locus.
|
20641034 |
2010 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These abnormal restriction fragments indicate that in each case a clonal proliferation of cells was present and also suggest that DNA alterations involving the parathyroid hormone locus may be important in the tumorigenesis or clonal evolution of some parathyroid adenomas.
|
3344017 |
1988 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One of 43 parathyroid adenomas showed a chromosome 11 rearrangement involving both the PTH gene on the short arm of chromosome 11 (at band p15) and a locus on the long arm (11q13).
|
2199477 |
1990 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report the detailed molecular characterization of a human parathyroid adenoma with a clonal parathyroid hormone gene rearrangement.
|
2011400 |
1991 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma.
|
2723071 |
1989 |
|
Parathyroid Adenoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overexpression of the cyclin D1 oncogene in 18% of our cases, due to the cyclin D1/PTH translocation and/or other mechanisms, suggests that overexpressed cyclin D1 plays a role in the pathogenesis of a much larger proportion of parathyroid adenomas than previously appreciated.
|
8626826 |
1996 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The vitamin D receptor gene (VDR) is a compelling candidate tumor suppressor gene for parathyroid adenomas based on existing evidence of the vitamin D system's antiproliferative actions in parathyroid and other tissues, its reported inhibition of PTH gene transcription, and the decreased expression of VDR mRNA and VDR protein observed in parathyroid adenomas.
|
17003089 |
2006 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differences in Tc-MIBI DPS, serum parathyroid hormone (PTH), serum calcium and phosphorus, as well as the weight and longest diameter of lesion between PA and PH were also compared.
|
30239472 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
THE RESULTS OF PARATHYROID HORMONE ASSAY IN PARATHYROID ASPIRATES IN PRE-OPERATIVE LOCALIZATION OF PARATHYROID ADENOMAS FOR FOCUSED PARATHYROIDECTOMY IN PATIENTS WITH NEGATIVE OR SUSPICIOUS TECHNETIUM-99M-SESTAMIBI SCANS.
|
28683236 |
2017 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primary hyperparathyroidism (pHPT) is characterized by excessive production of parathyroid hormone (PTH) due to parathyroid adenomas while uremic secondary HPT (sHPT) is caused by parathyroid hyperplasia in response to renal failure.
|
12444900 |
2002 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, on Northern blot analysis, there was a PTH messenger ribonucleic acid transcript with a size similar to that found in parathyroid adenoma or hyperplasia.
|
8077382 |
1994 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations: BNE</b> = bilateral neck exploration; <b>CT</b> = computed tomography; <b>IOPTH</b> = intra-operative parathyroid hormone; <b>MGD</b> = multi-gland disease; <b>MIBI</b> = sestamibi; <b>MIP</b> = minimally invasive parathyroidectomy; <b>MRI</b> = magnetic resonance imaging; <b>PHPT</b> = primary hyperparathyroidism; <b>PTA</b> = parathyroid adenoma; <b>PTH</b> = parathyroid hormone; <b>SGA</b> = single-gland adenoma; <b>SPECT</b> = single photon emission computed tomography; <b>4D</b> = four-dimensional.
|
30720353 |
2019 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of chronic elevation of PTH was evaluated in 20 patients affected by PHP at diagnosis and after surgical removal of parathyroid adenoma.
|
26068297 |
2015 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with cystic parathyroid adenomas had higher serum intact parathyroid hormone and calcium levels, larger maximum tumor diameter, and lower serum inorganic phosphorus level than did those with solid adenomas.
|
30123260 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
[<sup>18</sup>F]Fluorocholine Uptake of Parathyroid Adenoma Is Correlated with Parathyroid Hormone Level.
|
29508264 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A subset of parathyroid adenomas contains a clonal rearrangement that places the PTH gene's regulatory sequences in proximity to the cyclin D1 Oncogene causing its overexpression, and 20-40% of parathyroid adenomas overexpress the cyclin D1 protein.
|
10704427 |
2000 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Forty-one parathyroid adenomas from patients with symptomatic PHPT and ten normal parathyroid glands either from patients with PHPT (n=3) or from euthyroid patients without PHPT during thyroid surgery (n=7) were analyzed for vitamin D receptor (VDR), calcium-sensing receptor (CASR), cyclin D1 (CD1), and parathyroid hormone (PTH) expressions.
|
23660642 |
2013 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the analysed parameters including serum calcium and PTH and the size and weight of parathyroid adenomas, size was significantly different between patients with negative <sup>99m</sup>Tc-MIBI/tetrofosmin SPECT/CT and those with positive <sup>99m</sup>Tc-MIBI/tetrofosmin SPECT/CT (mean size 13.4 ± 7.6 mm vs. 16.9 ± 7.4 mm, respectively; p = 0.042).
|
29516131 |
2018 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the accuracy of the parathyroid hormone needle aspiration washout method in detecting the localization of parathyroid adenoma.
|
30834899 |
2019 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The inhibitory effect of Ca(2+) calmodulin on PTH secretion may be due to the absence of synaptotagmin 1 protein in parathyroid adenomas, as demonstrated by western blot analysis.
|
20974637 |
2011 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In primary culture of parathyroid adenoma (n = 9) and hyperplasia (n = 2), parathyroid hormone secretion was increased 2- to 15-fold with low calcium concentration (0.5 to 4.0 mmol/L CaCl 2 from 2 to 6 hours, P < .005).
|
15657585 |
2004 |
|
Parathyroid Adenoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In case of hypercalcemia, serum intact PTH and parathyroid imaging should be monitored to evaluate the presence of parathyroid adenoma with care because PHPT could present with inappropriate normal PTH.
|
29995768 |
2018 |