PTGS1, prostaglandin-endoperoxide synthase 1, 5742

N. diseases: 318; N. variants: 36
Disease: Cardiovascular Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.050 AlteredExpression group BEFREE Aspirin prevents cardiovascular disease and colon cancer; however aspirin's inhibition of platelet COX-1 only partially explains its diverse effects. 27566955 2016
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.050 GeneticVariation group BEFREE The frequency, risk factors, prognosis, and genetic polymorphism of the cyclooxygenase-1 (COX-1) gene for aspirin resistance have not been reported in elderly patients with CVD. 23038044 2013
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.050 GeneticVariation group BEFREE In conclusion, subjects homozygote for the variant allele of a COX-1 gene polymorphism represent a subpopulation of men with decreased PGF(2)(alpha) formation and lower prevalence of CVD. 19091535 2009
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.050 GeneticVariation group BEFREE These findings suggest that genetic variation in PTGS1 and PTGS2 may be important risk factors for the development of cardiovascular disease events. 17495879 2008
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.050 GeneticVariation group LHGDN These findings suggest that genetic variation in PTGS1 and PTGS2 may be important risk factors for the development of cardiovascular disease events. 17495879 2008
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.050 Biomarker group BEFREE the preventive effect of acetylsalicylic acid in cardiovascular disease may be due to inhibition of platelet aggregation mediated by COX-1, but may in addition be due to anti-inflammatory effects by inhibition of COX-2. 10942685 2000