PTGS1, prostaglandin-endoperoxide synthase 1, 5742

N. diseases: 43; N. variants: 18
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.520 Biomarker phenotype CTD_human The results of the study suggest participation of COX-1, COX-2 and iNOS, but not nNOS, in transmission of pain stimuli in STZ-induced diabetic hyperalgesia. 17989504 2008
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.360 Biomarker disease CTD_human Effects of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of ovarian carcinoma in vivo. 18488158 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.360 Biomarker disease CTD_human Effects of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of ovarian carcinoma in vivo. 18488158 2008
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.350 Biomarker group CTD_human Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. 12189197 2002
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer 		0.340 Biomarker disease CTD_human Improved antiulcer and anticancer properties of a trans-resveratrol analog in mice. 19066340 2009
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.340 Biomarker disease CTD_human Induction of cyclooxygenase-1 in cultured synovial cells isolated from rheumatoid arthritis patients. 15167967 2004
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer 		0.340 Biomarker disease CTD_human Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions. 10594344 1999
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET We found that levels of prostaglandin-endoperoxide synthase 1 (PTGS1; aka COX-1) and prostaglandin-endoperoxide receptor 3 (PTGER3) mRNA are increased, and levels of prostaglandin-endoperoxide synthase 2 (PTGS2; aka COX-2) mRNA are decreased, in older subjects with schizophrenia (> 40years of age) compared to matched normal controls or younger subjects with schizophrenia (< 40years of age). 22397921 2012
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.310 Biomarker phenotype CTD_human Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats. 17989504 2008
CUI: C0264423
Disease: Asthma, Occupational
Asthma, Occupational 		0.300 Biomarker disease CTD_human Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. 25721048 2016
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0010093
Disease: Corpus Luteum Cyst
Corpus Luteum Cyst 		0.300 Biomarker disease CTD_human New insights into the pathogenesis of cystic follicles in cattle: microarray analysis of gene expression in granulosa cells. 21239663 2011
CUI: C0029927
Disease: Ovarian Cysts
Ovarian Cysts 		0.300 Biomarker disease CTD_human New insights into the pathogenesis of cystic follicles in cattle: microarray analysis of gene expression in granulosa cells. 21239663 2011
CUI: C0018801
Disease: Heart failure
Heart failure 		0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C0023212
Disease: Left-Sided Heart Failure
Left-Sided Heart Failure 		0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C0235527
Disease: Heart Failure, Right-Sided
Heart Failure, Right-Sided 		0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C1959583
Disease: Myocardial Failure
Myocardial Failure 		0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C1961112
Disease: Heart Decompensation
Heart Decompensation 		0.300 Biomarker phenotype CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.300 Biomarker disease CTD_human Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure. 19420110 2009
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Biomarker phenotype CTD_human Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats. 17989504 2008
CUI: C0751211
Disease: Hyperalgesia, Primary
Hyperalgesia, Primary 		0.300 Biomarker phenotype CTD_human Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats. 17989504 2008
CUI: C0751212
Disease: Hyperalgesia, Secondary
Hyperalgesia, Secondary 		0.300 Biomarker phenotype CTD_human Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats. 17989504 2008
CUI: C0751213
Disease: Tactile Allodynia
Tactile Allodynia 		0.300 Biomarker phenotype CTD_human Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats. 17989504 2008
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal 		0.300 Biomarker phenotype CTD_human Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats. 17989504 2008