PTGS2, prostaglandin-endoperoxide synthase 2, 5743

N. diseases: 1234; N. variants: 27
Disease: polyps ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032584
Disease: polyps
polyps 		0.100 GeneticVariation phenotype BEFREE Herein, we investigated whether alterations in the COX-2 gene are involved in the development of extracolonic polyps and extragastrointestinal features. 10956391 2000
CUI: C0032584
Disease: polyps
polyps 		0.100 Biomarker phenotype BEFREE Offspring from cox-2 null by Apcdelta716 matings exhibit an 86% reduction in polyp number when compared to offspring from control animals, thus providing genetic evidence that COX-2 contributes to tumor formation or growth. 10630643 1999
CUI: C0032584
Disease: polyps
polyps 		0.100 AlteredExpression phenotype BEFREE However, COX-2 mRNA expression in nasal polyps from the AIAR group (0.38 +/- 0.10) was markedly and significantly lower than in polyps from the ATAR group (2.93 +/- 0. 10390414 1999