|
polyps
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Laser capture microdissection and in situ hybridization analysis show almost exclusive expression of Dio2 in the stroma of Apc<sup>Δ716</sup> polyps in the proximity of the COX-2-positive areas.
|
31215118 |
2019 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The Cysltr1-/- colonic polyps exhibited significant decreases in nuclear β-catenin and COX-2 protein expression, while the normal crypts surrounding the polyps exhibited increased Mucin 2 expression.
|
28410235 |
2017 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
All cases of JPC polyps with adenomatous change showed strong COX-2 expression.
|
27072264 |
2016 |
|
polyps
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
This study was done to investigate the associations of polymorphisms in COX2 gene with the risk of colorectal cancer or polyps development among Jordanian population and to correlate with other ethnicities.
|
25835114 |
2015 |
|
polyps
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Alternatively, celecoxib, an inhibitor of prostaglandin-endoperoxide synthase 2, reduced polyp numbers in Apc(Min/+) mice, liver metastasis in NSG mice with orthotopic tumors, and numbers of CSCs in Apc(Min/+) and NSG mice.
|
26261008 |
2015 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The expression of cyclooxygenase-2 and vascular endothelial growth factor in the endometrium during the peri-implantation period in women with and without polyps.
|
24471989 |
2014 |
|
polyps
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The number of COX-2-positive epithelial cells was significantly reduced in AH polyps (p < 0.04).
|
22123288 |
2012 |
|
polyps
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
After tissue culturing, the presence of COX-2 protein and LXA(4) (ELISA) was detected in CF polyps and turbinates and compared with that of the control group.
|
22185734 |
2012 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
High COX-2 levels correlated with increased cytoplasmic Hu-antigen R expression in JPS polyps (P = .022), but not in sporadic juvenile polyps.
|
19124115 |
2009 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Stromal expression of COX-2, MMP-2 and MMP-9 were found significantly higher in premenopausal polyps compared to postmenopausal polyps (p<0.05).
|
18378414 |
2008 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, any (1+/2+) COX-2 overexpression was more frequent in non-serrated adenomas (60% = 307/515) than in hyperplastic polyps (13% = 3/24, p < 0.0001) and serrated polyps (SSAs and mixed polyps) (25% = 3/12, p = 0.03).
|
18230181 |
2008 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Furthermore, any (1+/2+) COX-2 overexpression was more frequent in non-serrated adenomas (60% = 307/515) than in hyperplastic polyps (13% = 3/24, p < 0.0001) and serrated polyps (SSAs and mixed polyps) (25% = 3/12, p = 0.03).
|
18230181 |
2008 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
To determine whether germline and somatic loss of BMPR1A in polyps from a patient with juvenile polyposis syndrome have altered COX-2 expression, we characterized a patient with juvenile polyposis syndrome for BMPR1A germline mutations and examined the polyps for BMPR1A expression and COX-2 expression.
|
17325551 |
2007 |
|
polyps
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Treatments with COX-2-specific NSAIDs have been shown to reduce polyp size and polyp number in FAP patients with a predisposition to colorectal adenoma and cancer.
|
16391811 |
2006 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
A significantly higher proportion of endometrial polyps express aromatase compared with disease-free endometrium; however, no correlation was found between aromatase expression and changes in either Ki-67 or COX-2 expression during the menstrual cycle.
|
16723309 |
2006 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Results suggest that use of NSAIDs is associated with lower levels of COX-2 expression and that the protective effect of NSAIDs on polyp occurrence is stronger in the subgroup of cases with higher expression of COX-2 and a higher COX-2/COX-1 ratio.
|
15807932 |
2005 |
|
polyps
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Additionally, treatment with COX-2-selective inhibitors reduces polyp burden in animal models of intestinal neoplasia and in humans with familial adenomatous polyposis (FAP).
|
15285921 |
2004 |
|
polyps
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Celecoxib, the first US FDA approved selective COX-2 inhibitor, initially developed for the treatment of adult rheumatoid arthritis and osteoarthritis, has been reported to reduce the formation of polyps in patients with familial adenomatous polyposis.
|
15313405 |
2004 |
|
polyps
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Genetic interactions between Cox-2 and Lkb1 in polyp formation were analyzed in mice with combined deficiencies in these genes.
|
15480979 |
2004 |
|
polyps
|
0.100 |
Biomarker
|
phenotype |
LHGDN |
Immunoreactive COX-2 was predominantly and strongly expressed in interstitial cells in the sub-epithelial layer of 10 hyperplastic polyps.
|
14582702 |
2003 |
|
polyps
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The mean levels of COX-2 mRNA expression (0.25 +/- 0.06) and NF-kappaB activity (89 +/- 13) in nasal polyps from AIAR were significantly lower than in polyps from ATAR (COX-2 = 1.58 +/- 0.50, and NF-kappaB = 143 +/- 12, P < 0.01 and P < 0.05, respectively).
|
12622742 |
2003 |
|
polyps
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Subsequent examination of a large series of human PJS polyps revealed that COX-2 was also highly up-regulated in the majority of these polyps.
|
12218179 |
2002 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
LHGDN |
Subsequent examination of a large series of human PJS polyps revealed that COX-2 was also highly up-regulated in the majority of these polyps.
|
12218179 |
2002 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, stimulation of angiogenesis is one of the major effects by COX-2 expression that is induced in the polyp stromal cells.
|
11945149 |
2002 |
|
polyps
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Reactive intermediates formed during the arachidonic acid cascade, notably by COX-2, which is upregulated in polyps of FAP patients, may promote various stages of the polyp --> adenoma --> carcinoma sequence.
|
10861445 |
2000 |