|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The mRNA expression profile of GAMs displayed an upregulation of factors that are considered as pro-inflammatory M1 (eg, CCL2, CCL3L3, CCL4, PTGS2) and anti-inflammatory M2 polarization markers (eg, MRC1, LGMN, CD163, IL10, MSR1), the latter rather being associated with phagocytic functions in the GBM microenvironment.
|
30506802 |
2019 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, biotinylated PAMAM G3 dendrimers substituted with the recognized anticancer agents cyclooxygenase-2 (COX-2) inhibitor celecoxib and peroxisome proliferator-activated receptor γ (PPARγ) agonist Fmoc-L-Leucine (G3-BCL) were tested in vitro on human cell lines with different p53 status: glioblastoma (U-118 MG), normal fibroblasts (BJ) and immortalized keratinocytes (HaCaT).
|
31652556 |
2019 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The megameric conjugate with nimesulide was tested in vitro on three human cell lines: squamous cell carcinoma (SCC-15) and glioblastoma (U-118 MG) overexpressing cyclooxygenase-2 (COX-2), and normal skin fibroblasts (BJ).
|
31601050 |
2019 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Since COX-2 is over-expressed in subset of glioblastoma and is also induced in hypoxia, we studied combinations of a prototype Cyclooxygenase (COX-2) inhibitor, NS-398 with various drugs (BCNU, Temozolomide, 2-Deoxy-D-glucose and Cisplatin) for their ability to abrogate chemoresistance under both severe hypoxia (0.2% O<sub>2</sub>) and normoxia (20% O<sub>2</sub>) in glioma cells.
|
29719610 |
2018 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results showed, that biotinylated G3 PAMAM dendrimers substituted with COX-2 inhibitor, celecoxib, and PPARγ agonist, Fmoc-l-Leucine (1:1) may be a good candidate for local therapy of glioblastoma but not a skin cancer.
|
30118847 |
2018 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Elevated cyclooxygenase-2 (COX-2) and the associated inflammation within the brain contribute to glioblastoma development.
|
28718447 |
2017 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
COX-2/sEH dual inhibitor PTUPB suppresses glioblastoma growth by targeting epidermal growth factor receptor and hyaluronan mediated motility receptor.
|
29152086 |
2017 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our findings uncover an aberrant positive feedback interaction between the Cox-2/PGE2 and Wnt pathways that mediates the stem-like state in glioblastoma.
|
29137258 |
2017 |
|
Glioblastoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Integrative Oncogenomics Cancer Browser (IntroGen) analysis shows downregulation of COX-2 and amplification of MIF and/or p53 activity during development of glioblastomas, ependymoma, and colon adenomas.
|
29247872 |
2017 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Cyclooxygenase-2 in glioblastoma multiforme.
|
27693715 |
2017 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Cyclooxygenase-2 (COX-2) has been linked to GBMs and may contribute to their aggressive phenotypes.
|
28333553 |
2017 |
|
Glioblastoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Olive oil compounds inhibit the paracrine regulation of TNF-α-induced endothelial cell migration through reduced glioblastoma cell cyclooxygenase-2 expression.
|
26410343 |
2016 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Tumor-associated macrophages induce vasculogenic mimicry of glioblastoma multiforme through cyclooxygenase-2 activation.
|
27824617 |
2016 |
|
Glioblastoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Biphasic effects of luteolin on interleukin-1β-induced cyclooxygenase-2 expression in glioblastoma cells.
|
25409926 |
2015 |
|
Glioblastoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
More importantly, Aβ deposition mediated the inflammatory response of glial cells via inducing the expression of COX-2 in glioblastoma cells.
|
24621265 |
2014 |
|
Glioblastoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
COX-2 overexpression induces Id1 expression in two GBM cell lines suggesting a role for Id1 in glioma transformation/tumorigenesis.
|
24659686 |
2014 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2.
|
22406049 |
2012 |
|
Glioblastoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to analyze the methylation status of four critical tumor-associated genes (MGMT, RARbeta, RASSF1A, CDH13), and investigate possible links with inflammatory (interleukin [IL]-6, IL-8) and angiogenic mediators (vascular endothelial growth factor [VEGF], cyclooxygenase [COX]-2) and clinical outcome in 23 glioma samples (6 grade II astrocytomas, 17 grade IV glioblastomas).
|
19809523 |
2010 |
|
Glioblastoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Together, these findings indicate the existence of the nuclear EGFR/EGFRvIII signaling pathway in GBM and its functional interaction with STAT3 to activate COX-2 gene expression, thus linking EGFR-STAT3 and EGFRvIII-STAT3 signaling axes to proinflammatory COX-2 mediated pathway.
|
20145033 |
2010 |
|
Glioblastoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
The difference in Cox-2 expression between the classical and bizarre vascular pattern in glioblastomas was statistically significant (P = 0.047).
|
18181832 |
2008 |
|
Glioblastoma
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our data did not support our original observations relating individual IL-4Ralpha, IL-13, or COX-2 SNPs to glioblastoma risk.
|
18006935 |
2007 |
|
Glioblastoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the most promising vectors with E1/E4 under the control of the GFAP/Ki67 or E2F-1/COX-2 promoters, and the native Ad5 or the chimeric Ad5/35 fiber for their antineoplastic activity in a subcutaneous and intracranial glioblastoma xenograft model.
|
17640083 |
2007 |
|
Glioblastoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
The radiosensitive (A172) and radioresistant (T98G) Glioblastoma multiforme cell lines were assayed for COX-2 expression using standard immunofluorescence histochemistry.
|
15816645 |
2005 |
|
Glioblastoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A human glioma cell line, U-87MG, and primary cultured glioblastoma cells (MG-377) overexpressed COX-2.
|
15383564 |
2004 |
|
Glioblastoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398.
|
15105053 |
2004 |