Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Activation of PTGS2/NF-κB signaling pathway enhances radiation resistance of glioma.
|
30740906 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-β/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for human glioma.
|
31438982 |
2019 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the animal experiments, IATL reduced the size and weight of glioma tumors in xenograft mice and inhibited the expression of COX-2 and phosphorylated NF-κB p65 in the transplanted tumors.
|
30740911 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro.
|
31652556 |
2019 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A strong negative correlation was observed between the level of miR-26b and COX-2 in 30 glioma tissues.
|
28800785 |
2019 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, COX-2 and survivin may be sensitive predictors of a negative clinical prognosis for patients with glioma.
|
28789345 |
2017 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Paraffin-embedded glioma specimens were detected for the COX-2 expression using immunohistochemistry.
|
28306608 |
2017 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Further, targeting MET and Cox-2 may represent an attractive target therapy for glioma.
|
26097553 |
2015 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population.
|
25966079 |
2015 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased COX-2 expression directly correlates with glioma grade and is associated with shorter survival in glioblastoma (GBM) patients.
|
24659686 |
2014 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression analysis further revealed that Cox-2 was elevated in glioma and associated with survival of patients.
|
22406049 |
2012 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This led to our interest in assessing the response of glioma cell lines to treatment with celecoxib, a selective COX-2 inhibitor.
|
21220497 |
2011 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
COX-2 regulates the proliferation of glioma stem like cells.
|
21763744 |
2011 |
Glioma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the single-locus analysis of the 23 examined SNPs, 1 pro-inflammatory and 2 anti-inflammatory gene SNPs were significantly associated with glioma risk (COX2/PTGS2, rs20417 [OR = 1.41]; IL10, rs1800896 [OR = 1.57]; and IL13, rs20541 [OR = 0.39], respectively).
|
20406895 |
2010 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A CD133(+)-enriched U87 glioma cell population, isolated from parental U87 cells with magnetic cell sorting technology, also grew as neurospheres and showed enhanced COX-2 expression.
|
19272160 |
2009 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein kinase C-delta.
|
19169273 |
2009 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo.
|
19925030 |
2009 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The U87MG glioma cell line is a good model for COX-2 induction in glioma cell lines.
|
19029777 |
2008 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
The U87MG glioma cell line is a good model for COX-2 induction in glioma cell lines.
|
19029777 |
2008 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
All COX-2 inhibitors reduced proliferation of the glioma cell lines irrespective of their COX-2 expression level.
|
17729162 |
2007 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, treatment of glioma cell lines with prostaglandin E2, the predominant product of COX-2 activity, results in increased vascular endothelial growth factor expression, thus potentially linking elevations in COX-2 expression with tumor angiogenesis in malignant gliomas.
|
17616668 |
2007 |
Glioma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
We found that EGF-mediated stimulation of EGFR tyrosine kinase in human glioma cell lines induces expression of both COX-2 mRNA and protein.
|
17616668 |
2007 |
Glioma
|
0.400 |
Biomarker
|
disease |
CTD_human |
The induction of cyclooxygenase-2 (COX-2) expression is associated with more aggressive gliomas and poor survival.
|
15561105 |
2005 |
Glioma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Furthermore, our data show that pharmacological concentrations of celecoxib may interfere with the proapoptotic action of R(+)-MA and anandamide, suggesting that cotreatment with COX-2 inhibitors could diminish glioma regression induced by these compounds.
|
15361550 |
2004 |
Glioma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, our data show that pharmacological concentrations of celecoxib may interfere with the proapoptotic action of R(+)-MA and anandamide, suggesting that cotreatment with COX-2 inhibitors could diminish glioma regression induced by these compounds.
|
15361550 |
2004 |