Lung Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accordingly, EGFR and COX-2/TNF-α activation/induction is expected to play important roles in MGL deficiency-driven lung tumors.
|
29348400 |
2018 |
Lung Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results indicate that HSPA12B stimulates lung tumor growth via a Cox-2-dependent mechanism.
|
25909170 |
2015 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This shows that COX-2 activity is present during lung tumor development in a high HGF environment.
|
25057941 |
2014 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Together, these results support the idea that increased expression of the COX-2 product PGE(2) in the lung tumor microenvironment may initiate a mitogenic signaling cascade composed of EP4, betaArrestin1, and c-Src which mediates cancer cell migration.
|
20353998 |
2010 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We used COX-2 transcriptional restriction, in combination with transductional Ad hepatic untargeting and tumor retargeting by a bispecific adapter, sCARhMFE, composed of sCAR [the coxsackie/Ad receptor (CAR) ectodomain] and MFE-23 (a single-chain anti-CEA antibody), to untarget liver after i.v. administration of Ad vectors expressing firefly luciferase and to retarget virus to hepatic colorectal tumor xenografts and non-small cell lung tumor xenografts.
|
19147569 |
2009 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
COX-2/EGFR expression and survival among women with adenocarcinoma of the lung.
|
18453539 |
2008 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells.
|
18496814 |
2008 |
Lung Neoplasms
|
0.100 |
Biomarker
|
group |
LHGDN |
MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancer.
|
17851225 |
2008 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results suggest that Ang-(1-7) may decrease COX-2 activity and proinflammatory prostaglandins to inhibit lung tumor growth.
|
17363603 |
2007 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Specific components of prostanoid-signaling pathways are present in non-small cell lung cancer cells.
|
17611676 |
2007 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells.
|
16820889 |
2006 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results.
|
16786043 |
2006 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Total cyclooxygenase-2 mRNA levels correlate with vascular endothelial growth factor mRNA levels, tumor angiogenesis and prognosis in non-small cell lung cancer patients.
|
15704107 |
2005 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Cyclooxygenase-2-dependent activation of signal transducer and activator of transcription 3 by interleukin-6 in non-small cell lung cancer.
|
16278387 |
2005 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population.
|
15777967 |
2005 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Characterization of the prostaglandin biosynthetic pathway in non-small cell lung cancer: a comparison with small cell lung cancer and correlation with angiogenesis, angiogenic factors and metastases.
|
15870920 |
2005 |
Lung Neoplasms
|
0.100 |
Biomarker
|
group |
LHGDN |
Chemoprevention in lung cancer.
|
15375805 |
2004 |
Lung Neoplasms
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer.
|
14604894 |
2004 |
Lung Neoplasms
|
0.100 |
Biomarker
|
group |
LHGDN |
COX-2-dependent stabilization of survivin in non-small cell lung cancer.
|
14597555 |
2004 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer.
|
12789263 |
2003 |
Lung Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings highlight a novel mechanism contributing to maintenance of elevated COX-2 and PGE(2) in the lung tumor environment.
|
12591723 |
2003 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Our findings highlight a novel mechanism contributing to maintenance of elevated COX-2 and PGE(2) in the lung tumor environment.
|
12591723 |
2003 |
Lung Neoplasms
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Increased expression of COX-2 in the development of human lung cancers.
|
12086404 |
2002 |
Lung Neoplasms
|
0.100 |
Biomarker
|
group |
LHGDN |
Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion.
|
12393872 |
2002 |