PTGS2, prostaglandin-endoperoxide synthase 2, 5743

N. diseases: 1234; N. variants: 27
Disease: Prolapsed lumbar disc ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0281899
Disease: Prolapsed lumbar disc
Prolapsed lumbar disc 		0.030 AlteredExpression disease BEFREE Osthole exerts analgesic effect on radicular inflammatory pain in LDH rat model, by down-regulating the mRNA expression of the target gene of COX-2 via inhibiting ERK activation in the spinal dorsal horn. 28486232 2017
CUI: C0281899
Disease: Prolapsed lumbar disc
Prolapsed lumbar disc 		0.030 AlteredExpression disease BEFREE Moreover, higher expression of IL-21, IL-17, and COX-2 was found in the protein and mRNA levels in disc tissues from LDH patients than in normal disc tissues. 26742440 2015
CUI: C0281899
Disease: Prolapsed lumbar disc
Prolapsed lumbar disc 		0.030 Biomarker disease BEFREE However, the role of cyclooxygenase-2 in lumbar disc herniation has never been addressed. 12435978 2002