PTGS2, prostaglandin-endoperoxide synthase 2, 5743

N. diseases: 1234; N. variants: 27
Disease: Skin callus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376154
Disease: Skin callus
Skin callus 		0.020 Biomarker disease BEFREE Remarkably, intermittent PTH<sub>1-34</sub> administration increased proliferation of periosteal progenitor cells, restored callus formation on day 7, and enhanced bone formation on days 10, 14 and 21 in Cox-2-deficient mice. 29408411 2018
CUI: C0376154
Disease: Skin callus
Skin callus 		0.020 GeneticVariation disease BEFREE Callus leukotriene levels were 4-fold higher in mice homozygous for a targeted mutation in the COX-2 gene (COX-2(KO)), which indicated that arachidonic acid was shunted into the 5-LO pathway in the absence of COX-2. 21067431 2010