|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor.
|
30647111 |
2019 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclooxygenase 2 may be a potential therapeutic target for the treatment of ovarian cancer.
|
31822119 |
2019 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we tested hypothesis that COX-2 induces loss of expression of E-cadherin, with resulting promotion of cancer cells' invasiveness in ovarian cancer.
|
29932878 |
2018 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclooxygenase (COX)-1 and COX-2 have been reported to be the biomarkers of OC.
|
28599493 |
2017 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results showed the patients with higher COX-2 expression had a significantly poorer survival rate, COX-2 expression had the potential to be a prognostic marker of ovarian cancer.
|
29152148 |
2017 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to investigate the effects of plasmid-mediated RNA interference targeting of cyclooxygenase-2 (COX-2) on the biological behaviors of SKOV3 human ovarian cancer cells and to analyze the function of COX-2 in carcinogenesis and development of ovarian cancer.
|
25335121 |
2015 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the present study demonstrated that RNAi can effectively silence COX‑2 gene expression and inhibit the growth of ovarian cancer cells, which indicates that there is a potential of targeting COX‑2 as a novel gene therapy approach for the treatment of ovarian cancer.
|
24718658 |
2014 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In correlation with decreased ovarian cancer severity, concentrations of PGE2 and expression of COX-2 were diminished in ovaries of flaxseed-fed hens.
|
23978451 |
2013 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the EGFR/COX-2/CRM1 interaction might be involved in progression of ovarian cancer and patient prognosis.
|
21756326 |
2011 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data identify COX-2 as a potential biomarker and therapeutic target in distinct molecular subtypes of ovarian cancer.
|
19621391 |
2010 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data indicate that COX-2 induce cells viability and migration, moreover promote the proliferation of CAOV-3 via PI3-k/Akt signal pathway.
|
18798061 |
2008 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A correlation also was demonstrated between CRM1 and COX-2 expression in ovarian cancer tissue.
|
18306389 |
2008 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The findings of our study indicate that the increased expression of COX-2 and survivin in ovarian cancer is associated with one another and with several adverse clinicopathologic parameters, including reduced survival, thus suggesting a role of these molecules in disease progression.
|
18171606 |
2008 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells.
|
18362203 |
2008 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Herein we showed that IGF-I efficiently induced COX-2 expression and PGE(2) biosynthesis at physiologically relevant concentrations in human ovarian cancer cells.
|
17341442 |
2007 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These findings suggest that COX-2 may play a role in the progression of epithelial ovarian tumors and that COX-2 expression may contribute to ovarian tumor angiogenesis by stimulating VEGF expression. p53 may be responsible for the regulation of COX-2 expression.
|
16515599 |
2006 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, we conclude that TNF-alpha mediated signaling is uncoupled from the modulation of COX-2 expression in ovarian cancer.
|
16044148 |
2005 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The significance of cyclooxygenase-2 (COX-2) expression in ovarian cancer has been discussed.
|
15963707 |
2005 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Thus, we conclude that TNF-alpha mediated signaling is uncoupled from the modulation of COX-2 expression in ovarian cancer.
|
16044148 |
2005 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LPA contributes to the development, progression, and metastasis of ovarian cancer in part by inducing the expression of genes that contribute to proliferation, survival, or invasion, including cyclooxgenase-2 (COX-2) and matrix metalloproteinase-2 (MMP-2).
|
15781636 |
2005 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.
|
15838264 |
2004 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
From these results, it was suggested that PPARgamma activation might suppress COX-2 expression via the nuclear factor-kappaB pathway in the ovarian carcinoma cells and that low expression of PPARgamma and high expression of COX-2 might be involved in carcinogenesis and progression of ovarian tumours.
|
15266333 |
2004 |
|
ovarian neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whether COX-2 inhibitor therapy would be beneficial in the prevention and/or treatment of ovarian cancer, the most lethal gynecological malignancy worldwide, is not known.
|
12615701 |
2003 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results show that cytoplasmic HuR expression associates with poor outcome in ovarian cancer, and one plausible explanation for this finding may be related to the ability of HuR to induce COX-2 expression.
|
14633672 |
2003 |
|
ovarian neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that COX-2 expression might play an important role in ovarian cancer development and that COX-2 expression in ovarian adenocarcinomas is frequently associated with p53 protein accumulation.
|
12469191 |
2003 |