PTGS2, prostaglandin-endoperoxide synthase 2, 5743

N. diseases: 1234; N. variants: 27
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease BEFREE The COX-2 inhibitor celecoxib was found to have a significant positive effect on major depression, not only in single studies but also in meta-analyses. 31214060 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 GeneticVariation disease BEFREE This study investigated the effects of BanI polymorphism of cPLA2 gene and COX-2 rs4648308 genotypes on somatic symptoms and inflammatory marker in patients with MDD. 28108057 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease PSYGENET No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression. 21168919 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 GeneticVariation disease BEFREE No influence of PTGS2 polymorphisms on response and remission to antidepressants in major depression. 21168919 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.330 Biomarker disease PSYGENET Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels. 20034614 2010