PTGS2, prostaglandin-endoperoxide synthase 2, 5743

N. diseases: 1234; N. variants: 27
Disease: Tumor Angiogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Many experimental studies have demonstrated the importance of COX-2 in the tumor angiogenesis. 31533599 2020
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE The results of the present study suggest that PF-2341066 and celecoxib may inhibit the development of cholangiocarcinoma by downregulating the expression of c-Met and COX-2 to inhibit cell proliferation, promote apoptosis and prevent VEGF-mediated tumor angiogenesis. 29725387 2018
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE The significant correlation of VEGF expression with COX-2 expression and MCD may represent the roles of COX-2 and MCD in tumor angiogenesis by modulating VEGF production. 27577989 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Cyclooxygenase-2 (COX-2) is a critically important mediator of inflammation that significantly influences tumor angiogenesis, invasion, and metastasis. 28152501 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. 27558792 2017
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE COX-2 might mediate tumor angiogenesis and growth, and could be considered as a target for gastric cancer therapy. 21266034 2011
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Because hypoxia-inducible factor-1alpha (HIF-1alpha), its downstream target vascular endothelial growth factor (VEGF), and other angiogenic factors such as interleukin-8 (IL-8) and cyclooxygenase 2 (COX-2) play critical roles in neovascularization, we tested the hypothesis that the inhibitory effect of T3 on tumor angiogenesis is via regulation of these angiogenic factors. 18936210 2008
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Cyclooxygenase 2 (COX-2) has also been shown to contribute to tumor angiogenesis. 18373164 2008
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Finally, treatment of glioma cell lines with prostaglandin E2, the predominant product of COX-2 activity, results in increased vascular endothelial growth factor expression, thus potentially linking elevations in COX-2 expression with tumor angiogenesis in malignant gliomas. 17616668 2007
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Regulation of COX-2 mediated signaling by alpha3 type IV noncollagenous domain in tumor angiogenesis. 17426256 2007
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Moreover, Cox-2/PGE2/EP/VEGF pathway possibly also contributes to tumor angiogenesis in HCC. 17097688 2007
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE They also suggest that heparanase may play a novel role for COX-2 mediated tumor angiogenesis in breast-cancer progression. 16391819 2006
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Much evidence supports an important role for the inducible enzyme cyclooxygenase-2 (COX-2) in tumor angiogenesis. 16618763 2006
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Cyclooxygenase-2 (COX-2) affects cell proliferation, apoptosis, and metastasis of breast cancer, and may also be involved in tumor angiogenesis through vascular endothelial growth factor. 16507397 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Our work supports the COX-2/PGE2/HIF-1alpha/VEGF pathway possibly contributing to tumor angiogenesis in GC. 15864753 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Our aim was to study total COX-2 mRNA expression in both cancer cells and surrounding stromal cells and its association with angiogenic factor VEGF mRNA expression, tumor angiogenesis and prognosis in patients with NSCLC. 15704107 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Our results suggest that heparanase may play a novel role for COX-2-mediated tumor angiogenesis. 16299228 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Whereas COX-2 and PGE(2) are associated with cancer cell survival and tumor angiogenesis, arachidonic acid itself is a strong apoptotic signal that may facilitate cancer cell death. 15788676 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE A papillary thyroid carcinoma cell line TPC-1 was also studied in vitro to determine the role of the specific COX-2 inhibitor NS-398 on COX-2 and vascular endothelial growth factor-A, since COX-2 also has a role in regulating tumor angiogenesis. 15475935 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Elevated tumor cyclooxygenase 2 (COX-2) expression is associated with increased angiogenesis, tumor invasion, and promotion of tumor cell resistance to apoptosis. 15374938 2004
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE In experimental setting, at low levels NSAIDs downregulate the COX-2 gene in colorectal cancer cells, whereas at clinical relevant concentrations the production of prostaglandin E2 by enzymatic activity of COX-2 is diminished resulting in inhibition of the tumor angiogenesis. 15501074 2004
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Elevated tumor cyclooxygenase 2 (COX-2) expression is associated with increased angiogenesis, tumor invasion and promotion of tumor cell resistance to apoptosis. 14597555 2004
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE COX-2 may be involved in the course of tumor angiogenesis of colorectal cancer and acts through VEGF. 15285012 2004
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 Biomarker phenotype BEFREE Increased abundance of cyclooxygenase-2 correlates with vascular endothelial growth factor-A abundance and tumor angiogenesis in gastric cancer. 12767510 2003
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.100 AlteredExpression phenotype BEFREE Expression of COX-2 also was correlated with tumor angiogenesis but not with EGFR, Her-2/neu, or p53 expression. 14508829 2003