PTGS2, prostaglandin-endoperoxide synthase 2, 5743

N. diseases: 1234; N. variants: 27
Disease: Malignant neoplasm of soft tissue ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4551686
Disease: Malignant neoplasm of soft tissue
Malignant neoplasm of soft tissue 		0.030 AlteredExpression group BEFREE Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. 30502795 2018
CUI: C4551686
Disease: Malignant neoplasm of soft tissue
Malignant neoplasm of soft tissue 		0.030 AlteredExpression group BEFREE Although overexpression of COX-2 has been associated with poor prognosis and decreased survival in chondrosarcoma and osteosarcoma, no relationship between COX-2 expression and patient outcome has been demonstrated in rhabdomyosarcoma or adult soft tissue sarcomas. 21874258 2011
CUI: C4551686
Disease: Malignant neoplasm of soft tissue
Malignant neoplasm of soft tissue 		0.030 Biomarker group BEFREE Therefore, studies testing the efficacy of COX-2 inhibitors in the treatment of pediatric sarcomas are warranted. 12024286 2003