|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) plays a primary role in the development of humoral hypercalcemia of malignancy seen in the majority of adult T-cell leukemia/lymphoma (ATLL) patients with human T-cell lymphotropic virus type-1 (HTLV-1) infection.
|
15889157 |
2005 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The high levels of plasma PTHrP and the demonstrated predominant renal mechanism in this case of HCM are suspected to be the cause for its refractoriness to bone resorption inhibitors.
|
17188588 |
2007 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
One peak eluted at a position between PTHrP (1-141) and cytochrome C and the other at a position identical to cytochrome C. These results suggest that PTHrP molecules with a molecular size equal to or greater than cytochrome C participate as causative agents of HHM.
|
1997102 |
1991 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP appears as the major causative agent in humoral hypercalcemia of malignancy (HHM) associated to a broad range of tumors.
|
16223565 |
2006 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is the cause of humoral hypercalcaemia of malignancy and interacts with parathyroid hormone (PTH) receptors.
|
9390035 |
1997 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have recently purified and cloned a parathyroid hormone-related protein (PTHrP) implicated in HHM from a human lung cancer cell line (BEN).
|
2693318 |
1989 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased PTHrP gene expression in and secretion of PTHrP by specific tumors directly contributes to the development of malignancy-associated hypercalcemia in vivo.
|
1280327 |
1992 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Over the past decade, studies have shown that parathyroid hormone-related protein is the cause of the HHM syndrome, and recent data suggest that this protein may also play a paracrine role in some patients with local osteolytic hypercalcemia.
|
8198376 |
1994 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The SCID/beige mouse model mimics HHM as it occurs in ATL patients, and will be useful to investigate the regulation of PTHrP expression by ATL cells in vivo.
|
11395400 |
2001 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
In case one, the serum levels and immunostaining for parathyroid hormone-related protein (PTHrP) verified humoral hypercalcemia of malignancy (HHM).
|
29951343 |
2018 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is produced by various neoplasms and is known to be a causative factor of hypercalcemia of malignancy.
|
11029801 |
2000 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, ectopic expression of EGFR in a receptor-low but AREG-expressing cell line increased PTHrP mRNA levels in vitro, and induced the capability to cause HHM and rapid osteolytic growth in vivo.
|
19825997 |
2009 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are important factors in the pathogenesis of HHM in ATLL and the expression of PTHrP can be activated by nuclear factor kappaB (NF-kappaB).
|
18089816 |
2007 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The relative abundance of PTHrP mRNA expressed in two of the adenomata was similar to that of a tumour (DAF) associated with humoral hypercalcaemia of malignancy, whereas PTHrP mRNA was of low abundance in a third and was undetectable in the fourth.
|
2066698 |
1991 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We previously showed that ATLL cells constitutively express high levels of PTHrP via activation of promoters P2 and P3, resulting in HHM.
|
17554373 |
2007 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
There appears to be little doubt that PTH-rP is the major mediator of hypercalcemia in patients with HHM, although it is possible that other factors (e.g., bone resorbing cytokines) also could contribute in some patients.
|
9362423 |
1997 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) that causes hypercalcemia of malignancy appears to function as an endogenous smooth muscle relaxant.
|
28656682 |
2017 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is a primary factor in the pathogenesis of malignancy-associated hypercalcemia.
|
9610565 |
1998 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP, a mediator of humoral hypercalcemia of malignancy, is considered as a potential activator to induce breast cancer cells metastasizing to bone.
|
20401668 |
2011 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is the major mediator of the humoral hypercalcemia of malignancy and of malignant osteolysis associated with skeletal metastases of common epithelial cancers.
|
10942719 |
2000 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that TGF-beta increased PTHrP production and mRNA expression in malignant keratinocytes and suggest that TGF-beta may be an important factor in the pathogenesis of humoral hypercalcemia of malignancy.
|
8194469 |
1994 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of PTHLH and high levels of circulating IL6 in OCCA patients may explain the frequent occurrence of hypercalcemia of malignancy and thromboembolic events in OCCA.
|
21343371 |
2011 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP is produced by tumors associated with the syndrome of humoral hypercalcemia of malignancy giving rise to the parathyroid hormone (PTH)-like symptoms characteristic of the syndrome.
|
1935171 |
1991 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHRP) is in part responsible for the clinical syndrome of hypercalcaemia of malignancy and has been implicated as an important factor in the development of bone metastases.
|
12374685 |
2002 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|