|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest PTHrP as a major cause of HHM.
|
3137193 |
1988 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have recently purified and cloned a parathyroid hormone-related protein (PTHrP) implicated in HHM from a human lung cancer cell line (BEN).
|
2693318 |
1989 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
The field has evolved rapidly and provides an example of fruitful clinical investigation: the original problem was a clinical one (the HHM syndrome); understanding the clinical disorder led to pursuit of the problem in the laboratory (adenylate cyclase assays, protein purification, molecular cloning, PTHRP synthesis); and observations made in the laboratory have rapidly yielded clinical fruits (PTHRP immunoassays) and opened a new window on normal physiology.
|
2172279 |
1990 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
One peak eluted at a position between PTHrP (1-141) and cytochrome C and the other at a position identical to cytochrome C. These results suggest that PTHrP molecules with a molecular size equal to or greater than cytochrome C participate as causative agents of HHM.
|
1997102 |
1991 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The relative abundance of PTHrP mRNA expressed in two of the adenomata was similar to that of a tumour (DAF) associated with humoral hypercalcaemia of malignancy, whereas PTHrP mRNA was of low abundance in a third and was undetectable in the fourth.
|
2066698 |
1991 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP is produced by tumors associated with the syndrome of humoral hypercalcemia of malignancy giving rise to the parathyroid hormone (PTH)-like symptoms characteristic of the syndrome.
|
1935171 |
1991 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Increased PTHrP gene expression in and secretion of PTHrP by specific tumors directly contributes to the development of malignancy-associated hypercalcemia in vivo.
|
1280327 |
1992 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
A parathyroid hormone-related protein (PTHrP) has been identified, isolated and cloned, which is most likely responsible for the calcium disturbances in HHM, PTHrP is a previously unrecognized hormone which has limited amino-terminal sequence homology with PTH and is the product of a separate gene.
|
1525053 |
1992 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
The interaction of SCC with fibroblasts, possibly occurring during the invasive phase of SCC, may be the stimulus for enhanced PLP production, thus contributing to the genesis of humoral hypercalcemia of malignancy in this type of cancer (Cancer Res 50:3589-3594, 1990).
|
1732383 |
1992 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is an important humoral factor in the syndrome of humoral hypercalcaemia of malignancy (HHM) and its importance is evident by the many studies examining either PTHrP mRNA expression, intracellular peptide, or circulating PTHrP levels in patients with malignancy.
|
8277370 |
1993 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHRP) is expressed in a large number of tumors and is the mediator of parathyroid hormone-like effects seen in humoral hypercalcemia of malignancy.
|
7692947 |
1993 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
We report a case of hypercalcaemia of malignancy secondary to parathyroid hormone-related protein in a woman with renal carcinoma.
|
8287589 |
1993 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Over the past decade, studies have shown that parathyroid hormone-related protein is the cause of the HHM syndrome, and recent data suggest that this protein may also play a paracrine role in some patients with local osteolytic hypercalcemia.
|
8198376 |
1994 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that TGF-beta increased PTHrP production and mRNA expression in malignant keratinocytes and suggest that TGF-beta may be an important factor in the pathogenesis of humoral hypercalcemia of malignancy.
|
8194469 |
1994 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results confirmed that gynecological malignancies, although rarely associated with humoral hypercalcemia of malignancy (HHM), stained for PTHrP in a majority of the squamous-cell carcinomas (SCC) at all sites, but only in a minority of adenocarcinomas, and then in areas of squamous metaplasia.
|
8314318 |
1994 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Despite their high frequency of expression of PTHrP, cervical tumors seldom give rise to humoral hypercalcemia of malignancy, but the autocrine/paracrine effects of PTHrP may be important in the growth and dedifferentiation of the malignant cell population.
|
8004587 |
1994 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although PTHrP was discovered because of its production by cancers, evidence for its actions as a local regulator highlights the importance of understanding its roles not only in the etiology of HHM in cancer patients but also in normal tissues.
|
7495499 |
1995 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP gene amplification was also detected in one of five other tumors associated with humoral hypercalcemia of malignancy.
|
8768840 |
1996 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP), a major factor in the pathogenesis of humoral hypercalcemia of malignancy, is produced by many squamous carcinoma cells (SCCs).
|
8921834 |
1996 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is the cause of humoral hypercalcaemia of malignancy and interacts with parathyroid hormone (PTH) receptors.
|
9390035 |
1997 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
There appears to be little doubt that PTH-rP is the major mediator of hypercalcemia in patients with HHM, although it is possible that other factors (e.g., bone resorbing cytokines) also could contribute in some patients.
|
9362423 |
1997 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
PTHrP was the causative factor for HHM in this case.
|
9042805 |
1997 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid hormone-related protein (PTHrP) is a primary factor in the pathogenesis of malignancy-associated hypercalcemia.
|
9610565 |
1998 |
|
Humoral hypercalcemia of malignancy (disorder)
|
0.400 |
Biomarker
|
disease |
BEFREE |
Parathyroid-hormone-related protein (PTHrP) is the main mediator of the humoral hypercalcemia of malignancy.
|
9422518 |
1998 |