MIR451A, microRNA 451a, 574411

N. diseases: 177; N. variants: 2
Disease: Carcinoma of bladder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.030 Biomarker disease BEFREE However, our dual-luciferase reporter assay validated that c-Myc, an oncogene in many tumors, was a direct target gene of miR-451 in bladder cancer. 27571748 2016
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.030 AlteredExpression disease BEFREE Analysis of a microRNA (miRNA) expression signature of bladder cancer (BC) by deep-sequencing revealed that clustered miRNAs microRNA (miR)-451a, miR-144-3p, and miR-144-5p were significantly downregulated in BC tissues. 26057453 2015
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.030 Biomarker disease BEFREE In conclusion, miR451 should be a tumor-suppressing gene in bladder cancer. miR-451 could maintain the bladder tumor cells in epithelial phenotype, inhibit EMT process, thereby reducing the invasion and migration of tumor cells. 25550801 2014