SLC12A5, solute carrier family 12 member 5, 57468

N. diseases: 135; N. variants: 20
Disease: nervous system disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.040 Biomarker group BEFREE The small-molecule compounds described in our study may have therapeutic effects not only in RTT but also in other neurological disorders involving dysregulation of KCC2. 31366578 2019
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.040 Biomarker group BEFREE Here, we discuss the implications of KCC2 in neurological disease and consider the evolving evidence for KCC2's potential as a therapeutic target. 31240228 2019
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.040 Biomarker group BEFREE Aberrant KCC2 function contributes to human neurological disorders including epilepsy and neuropathic pain. 29028184 2017
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.040 Biomarker group BEFREE These pre-clinical data support prochlorperazine for a new therapeutic indication in the treatment of spasticity post-SCI and neurological disorders involving a KCC2 dysfunction. 28747093 2017