NLGN4X, neuroligin 4 X-linked, 57502

N. diseases: 6; N. variants: 6
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.500 Biomarker disease CTD_human Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. 12669065 2003
CUI: C1510586
Disease: Autism Spectrum Disorders
Autism Spectrum Disorders 		0.400 Biomarker disease CTD_human Notwithstanding complexities, our results further implicate the SHANK3-NLGN4-NRXN1 postsynaptic density genes and also identify novel loci at DPP6-DPP10-PCDH9 (synapse complex), ANKRD11, DPYD, PTCHD1, 15q24, among others, for a role in ASD susceptibility. 18252227 2008
CUI: C1845334
Disease: ASPERGER SYNDROME, X-LINKED, SUSCEPTIBILITY TO, 2 (finding)
ASPERGER SYNDROME, X-LINKED, SUSCEPTIBILITY TO, 2 (finding) 		0.400 Biomarker disease CTD_human
CUI: C1845539
Disease: AUTISM, X-LINKED, SUSCEPTIBILITY TO, 2 (finding)
AUTISM, X-LINKED, SUSCEPTIBILITY TO, 2 (finding) 		0.400 Biomarker disease GENOMICS_ENGLAND
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 Biomarker disease PSYGENET We found that, after experiment-wide correction, two SNPs on the X chromosome were associated significantly with alcohol dependence in European-American men (P = 1.0 × 10 for rs5916144 and P = 5.5 × 10 for rs5961794 at 3' UTR of NLGN4X), but not in the women. 23907288 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.300 GeneticVariation disease UNIPROT