|
Mild thrombocytopenia
|
0.300 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.
|
26224645 |
2015 |
|
Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)
|
0.300 |
FusionGene
|
disease |
ORPHANET |
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes.
|
19357394 |
2009 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
Furthermore, depletion of MRTF-A abolished the upregulation of COL1A1 in response to the TGF-β or Wnt signaling, indicating the importance of MRTF-A in the synthesis of type I collagen in breast cancer.
|
29807221 |
2018 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Furthermore, depletion of MRTF-A abolished the upregulation of COL1A1 in response to the TGF-β or Wnt signaling, indicating the importance of MRTF-A in the synthesis of type I collagen in breast cancer.
|
29807221 |
2018 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to investigate whether the genetic polymorphism rs12665607 of ESR1, rs10995190 of ZNF365, rs3817198 of LSP1 and rs17001868 of SGSM3/MKL1 are associated with the development of breast cancer (BC) in the Chinese women.
|
27432265 |
2017 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
miR-219a-5p inhibits breast cancer cell migration and epithelial-mesenchymal transition by targeting myocardin-related transcription factor A.
|
29077787 |
2017 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our data thus provide important and novel insights into MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration.
|
28822708 |
2017 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results demonstrated a novel pathway through which miR-93-5p regulates MKL-1 and STAT3 to affect EMT controlling breast cancer cell migration.
|
28499590 |
2017 |
|
Malignant neoplasm of breast
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
MKL1 and SRF were further demonstrated to promote the expression of <i>IL11</i>, which is essential for miR-206's function in inhibiting both invasion and stemness of breast cancer.<b>Conclusions:</b> The identification of the miR-206/TWF1/MKL1-SRF/IL11 signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis.<i></i>.
|
27435395 |
2017 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
miR-219a-5p inhibits breast cancer cell migration and epithelial-mesenchymal transition by targeting myocardin-related transcription factor A.
|
29077787 |
2017 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to investigate whether the genetic polymorphism rs12665607 of ESR1, rs10995190 of ZNF365, rs3817198 of LSP1 and rs17001868 of SGSM3/MKL1 are associated with the development of breast cancer (BC) in the Chinese women.
|
27432265 |
2017 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
MKL1 and SRF were further demonstrated to promote the expression of <i>IL11</i>, which is essential for miR-206's function in inhibiting both invasion and stemness of breast cancer.<b>Conclusions:</b> The identification of the miR-206/TWF1/MKL1-SRF/IL11 signaling pathway sheds lights on the understanding of breast cancer initiation and progression, unveils new therapeutic targets, and facilitates innovative drug development to control cancer and block metastasis.<i></i>.
|
27435395 |
2017 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our data thus provide important and novel insights into MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration.
|
28822708 |
2017 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results demonstrated a novel pathway through which miR-93-5p regulates MKL-1 and STAT3 to affect EMT controlling breast cancer cell migration.
|
28499590 |
2017 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Using the chi-squared (χ<sup>2</sup>) test and genetic model analysis, we found an association with BC for four SNPs (rs616488 (1p36.22/PEX14), rs6678914 (1q32.1/LGR6), rs17530068 (6q14/unknown) and rs6001930 (22q13.1/MKL1)) at a 5% level.
|
27604554 |
2016 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Using the chi-squared (χ<sup>2</sup>) test and genetic model analysis, we found an association with BC for four SNPs (rs616488 (1p36.22/PEX14), rs6678914 (1q32.1/LGR6), rs17530068 (6q14/unknown) and rs6001930 (22q13.1/MKL1)) at a 5% level.
|
27604554 |
2016 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results demonstrated the involvement of p300 in the MRTF-A mediated gene regulation and breast cancer cell migration.
|
26476216 |
2015 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
These results demonstrated the involvement of p300 in the MRTF-A mediated gene regulation and breast cancer cell migration.
|
26476216 |
2015 |
|
Breast Carcinoma
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
Malignant neoplasm of breast
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
This study highlights a crucial role for the transcriptional regulator Mkl1 and its SAP domain during breast cancer progression.
|
24495796 |
2014 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
But the exact molecular mechanism on metastasis is still not fully understood; we now report that both MRTF-A and STAT3 play important role in breast cancer migration of MDA-MB-231 cells.
|
25038455 |
2014 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines.
|
24721635 |
2014 |
|
Breast Carcinoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines.
|
24721635 |
2014 |
|
Breast Carcinoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
This study highlights a crucial role for the transcriptional regulator Mkl1 and its SAP domain during breast cancer progression.
|
24495796 |
2014 |