|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we investigated the regulation of CTGF transcription by megakaryocytic leukemia 1 (MKL1).
|
31637729 |
2020 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Megakaryocytic leukemia 1 (MKL1) mediates high glucose induced epithelial-mesenchymal transition by activating LOX transcription.
|
30553442 |
2019 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the mechanism by which megakaryocytic leukemia 1 (MKL1) mediates palmitate (PA) induced CRP transcription in hepatocytes.
|
31356989 |
2019 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor and together regulate transcription of actin cytoskeleton genes.
|
31582539 |
2019 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1), as a transcription coactivity factor, involved in cancer metastasis and cell differentiation.
|
29391067 |
2018 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Active SRF along with its coactivator megakaryoblastic leukemia 1 (MKL1) binds DNA near hedgehog target genes and forms a previously unknown protein complex with the hedgehog transcription factor glioma-associated oncogene family zinc finger-1 (GLI1), causing amplification of GLI1 transcriptional activity.
|
29400712 |
2018 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1) was closely related to the pathogenesis of various human malignant cancers.
|
30426547 |
2018 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recurrent and mutually exclusive chimeric gene fusions associated with pediatric AMKL are found in 60%-70% of cases and include RBM15-MKL1, CBFA2T3-GLIS2, NUP98-KDM5A and MLL rearrangements.
|
29427526 |
2018 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
We evaluated the potential role of megakaryocytic leukemia 1 (MKL1), as a bridge linking epigenetic activation of NOX to ROS production and cardiac ischemia-reperfusion injury.
|
30018168 |
2018 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we report that the transcriptional modulator megakaryocytic leukemia 1 (MKL1) is activated by H<sub>2</sub>O<sub>2</sub> treatment in skeletal muscle cells (C2C12).
|
30056131 |
2018 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both (megakaryoblastic leukemia)/myocardin-like 1 (MKL-1) and Signal transducer and activator of transcription 3 (STAT3) have been implicated in the control of cellular metabolism, survival and growth.
|
28499590 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we investigated the effects of cAMP-induced cytoskeletal remodelling on the serum response factor (SRF) co-factors Megakaryoblastic Leukemia-1 and -2 (MKL1 and MKL2) and their role in controlling VSMC and EC proliferation and migration.
|
28623279 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Primary tubular cells were also subjected to viral overexpression of megakaryoblastic leukemia 1 (MKL1) and MKL1 inhibition by the MKL1 inhibitor CCG-1423.
|
29065889 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previously we have reported that the transcriptional regulator megakaryocytic leukemia 1 (MKL1) plays a role programming cellular inflammatory response by modulating NF-κB activity.
|
28571745 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show here that megakaryocytic leukemia 1 (MKL1) is an epigenetic mediator of TNF-α-induced proinflammatory transcription.
|
28218970 |
2017 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
NUP98/KDM5A, CBFA2T3/GLIS2, KMT2A-rearranged lesions and monosomy 7 (NCK-7) independently predicted a poor outcome, compared with RBM15/MKL1-rearranged patients and those with AMKL not carrying these molecular lesions.
|
27114462 |
2016 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1) is highly expressed in the nervous system and plays a potentially principal role in neuronal migration and morphology.
|
27507698 |
2016 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this issue of Blood, Record et al report a novel human primary neutrophil immunodeficiency disorder caused by megakaryoblastic leukemia 1 (MKL1) mutation.
|
26405212 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1), also known as MAL or myocardin-related transcription factor A (MRTF-A), is a coactivator of serum response factor, which regulates transcription of actin and actin cytoskeleton-related genes.
|
26224645 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor (SRF) that promotes the expression of genes associated with cell proliferation, motility, adhesion, and differentiation-processes that also involve dynamic cytoskeletal changes in the cell.
|
26554816 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On the basis of frequency and prognosis, AMKL can be classified to 3 risk groups: good risk-7p abnormalities; poor risk-normal karyotypes, -7, 9p abnormalities including t(9;11)(p22;q23)/MLL-MLLT3, -13/13q-, and -15; and intermediate risk-others including t(1;22)(p13;q13)/OTT-MAL (RBM15-MKL1) and 11q23/MLL except t(9;11).
|
26215111 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phagocytosis of ACs by splenic MZMs required the megakaryoblastic leukemia 1 (MKL1) transcriptional coactivator-mediated mechanosensing pathway, which was maintained by MZ B cells through expression of membrane lymphotoxin-α1β2 (mLT).
|
26098211 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mammary tissue preirradiation induced Mkl1 nuclear translocation in the tumor cells in vivo, indicating activation of Mkl1 signaling.
|
25999144 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We demonstrate here that the transcriptional modulator megakaryocytic leukemia 1 (MKL1) was activated by hypoxia and transforming growth factor (TGF-β), two prominent pro-malignancy factors, in cultured lung cancer cells.
|
25746000 |
2015 |
|
Acute Megakaryocytic Leukemias
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previous studies showed that the transcriptional regulator megakaryoblastic leukemia-1 (Mkl1) induces tenascin-C expression in normal and transformed mammary epithelial cells.
|
24495796 |
2014 |