PTN, pleiotrophin, 5764

N. diseases: 164; N. variants: 4
Disease: Malignant neoplasm of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.070 AlteredExpression disease BEFREE Pleiotrophin (PTN) is a secreted cytokine that is expressed in various cancer cell lines and human tumor such as colon cancer, lung cancer, gastric cancer and melanoma. 28562667 2017
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.070 Biomarker disease BEFREE Pleiotrophin (PTN), an angiogenic factor, is associated with various types of cancer, including lung cancer. 25743809 2015
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.070 Biomarker disease BEFREE These findings provide mechanistic insights into the molecular basis for menin/PTN-mediated regulation of A549 lung cancer cell migration. 20639902 2010
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.070 Biomarker disease BEFREE Together, our findings indicate that menin suppresses lung cancer partly through increasing Polycomb gene-mediated H3K27 methylation and repressing PTN transcription, unraveling a novel, epigenetically regulated PTN-ALK signaling pathway in suppressing lung cancer. 19749796 2009
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.070 Biomarker disease BEFREE Our study suggests that pleiotrophin may be an early indicator of lung cancer and might be of use in monitoring the efficacy of therapy, which needs to be confirmed by larger studies. 11953815 2002
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.070 AlteredExpression disease BEFREE Differential expression and biological activity of the heparin-binding growth-associated molecule (HB-GAM) in lung cancer cell lines. 9389569 1997
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.070 AlteredExpression disease BEFREE Conversely, all of the resected lung cancers (n = 20) expressed MK but only one expressed PTN. 8217186 1993