CIP2A, cellular inhibitor of PP2A, 57650

N. diseases: 141; N. variants: 1
Disease: Myeloid Leukemia, Chronic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.040 Biomarker disease BEFREE KIAA1524 (also termed CIP2A), an oncoprotein inhibiting PP2A, is associated with disease progression in chronic myeloid leukaemia and may be prognostic in cytogenetically normal acute myeloid leukaemia. 28340282 2017
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.040 Biomarker disease BEFREE Second generation tyrosine kinase inhibitors prevent disease progression in high-risk (high CIP2A) chronic myeloid leukaemia patients. 25765543 2015
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.040 AlteredExpression disease BEFREE CIP2A is overexpressed in CML-CP patients, and its expression may promote CML pathogenesis. 25023053 2014
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.040 Biomarker disease BEFREE The data show that CIP2A is biologically and clinically important in CML and may be a novel therapeutic target. 21490338 2011