CIP2A, cellular inhibitor of PP2A, 57650

N. diseases: 141; N. variants: 1
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease BEFREE The p90 ribosomal S6 kinase (RSK), an important ERK effector, activates YB-1 to drive melanoma growth. 30356079 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease BEFREE Using S100B overexpression and shRNA(S100B) knockdown studies in melanoma cell lines, elevated S100B was found to enhance cell viability and modulate MAPK signaling by binding directly to the p90 ribosomal S6 kinase (RSK). 24627490 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease BEFREE We then used the Dual-Luciferase assay system, quantitative real-time RT-PCR (qRT-PCR), and Western blot analysis to determine that miR-218 targeted the 3'-UTR of the oncogenes CIP2A and BMI1 and thus regulated the biological process of melanoma. 24839010 2014