Here, we not only proved that the expression of CIP2A is positively correlated with lymph-node metastasis and cervical-cancer progression, but also revealed a close correlation between the protein's expression and the expression levels of two core epithelial-to-mesenchymal transition (EMT) markers, Vimentin and Snail.
However the number of samples analyzed in this preliminary study is limited and a large prospective cohort study is necessary to further evaluate CIP2A as a biomarker for cervical cancer.
CIP2A protein was detected in 52.8% of cervical cancer (n=72) and 12.5% of CIN III tissues (n=24) but not in normal (n=15), CIN I (n=21) or CIN II samples (n=25).