|
Lupus Erythematosus, Systemic
|
0.140 |
Biomarker
|
disease |
BEFREE |
Our findings provide a novel functional link underlying the mechanism of SLE in which WDFY4 influences B cell fate via noncanonical autophagy.
|
30257884 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
|
26663301 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture.
|
26606652 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.140 |
Biomarker
|
disease |
BEFREE |
E26 transformation-specific-1 (ETS1) and WDFY family member 4 (WDFY4) are closely related with systemic lupus erythematosus.
|
24549174 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
This effect was further confirmed by YY1 small interfering RNA knockdown, overexpression and chromatin immunoprecipitation experiments. rs877819 in WDFY4 might be the functional site associated with SLE by reduced binding of YY1 and downregulating WDFY4 expression.
|
22972472 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.
|
20169177 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
With these studies, it has been established that a number of genes associated with SLE in Caucasians are also risk factors in Asians: HLA class II genes, STAT4, BANK1, BLK, IRF5, TNFSF4, ITGAM, etc., while there are also novel genetic risk factors identified by these studies in Asians, for instance, the ETS1 and WDFY4 in Chinese.
|
20947545 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.
|
20169177 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |