|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variation in DENND1A was strongly associated with PCOS in the study cohort (p(combined cohorts)=10(-8)); multiple variants in THADA were also associated with PCOS, while there was no significant evidence for association of LHCGR variation with PCOS.
|
22180642 |
2012 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To conclude we demonstrated lack of association of DENND1A SNPs rs10818854, rs2479106, and rs10986105, previously associated with PCOS in Asians, with PCOS in Bahraini Arab women.
|
25626177 |
2015 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In a previous genome-wide association study, the SNP variants rs13429458, rs12478601, rs2479106, rs10818854 and rs13405728 in the THADA, DENND1A and LHCGR genes were identified as being independently associated with PCOS.
|
23208300 |
2013 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
It was suggested that the TT genotype of LHCGR rs13405728, CC genotype of THADA rs12478601 and AG + GG genotype of DENND1A rs2479106 had poor outcomes of IVF-ET in treating PCOS.
|
30844144 |
2019 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We therefore sequenced the DENND1A gene in white patients with PCOS to identify possible alterations that may be implicated in the PCOS pathogenesis.
|
24086769 |
2013 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry.
|
22547425 |
2012 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
|
21151128 |
2011 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Minor allele frequency of rs10818854 and rs10986105 DENND1A variants were significantly higher among women with PCOS.
|
29325736 |
2018 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
|
22885925 |
2012 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the polycystic ovary syndrome (PCOS) related single nucleotide polymorphisms (SNPs) rs13405728 (in gene LHCGR), rs13429458 (in gene THADA) and rs2479106 (in gene DENND1A) in women with endometrial carcinoma.
|
22902918 |
2012 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.
|
30566500 |
2018 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
|
22885925 |
2012 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, significant increase of PCOS risk was found between DENND1A-rs10818854 and PCOS susceptibility.
|
26757598 |
2016 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our previous research had identified three susceptibility loci (rs2479106, DENND1A; rs13405728, LHCGR; rs13429458, THADA) for PCOS in Han Chinese women.
|
25978310 |
2015 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
|
21151128 |
2011 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis.
|
27488699 |
2016 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variants in DENND1A (P = .0002), THADA (P = .035), FSHR (P = .007), and INSR (P = .046) were associated with PCOS in Europeans.
|
25303487 |
2015 |
|
Anxiety
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Studying the effects of haplotype partitioning methods on the RA-associated genomic results from the North American Rheumatoid Arthritis Consortium (NARAC) dataset.
|
30891314 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Nervousness
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Item-level analyses reveal genetic heterogeneity in neuroticism.
|
29500382 |
2018 |
|
Myopia, Degenerative
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
|
23049088 |
2012 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.
|
30718901 |
2019 |