|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
It was suggested that the TT genotype of LHCGR rs13405728, CC genotype of THADA rs12478601 and AG + GG genotype of DENND1A rs2479106 had poor outcomes of IVF-ET in treating PCOS.
|
30844144 |
2019 |
|
Polycystic Ovary Syndrome
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our findings provide additional evidence that DENND1A plays a central role in PCOS and suggest that rare noncoding variants contribute to disease pathogenesis.
|
31038695 |
2019 |
|
Polycystic Ovary Syndrome
|
0.200 |
Biomarker
|
disease |
BEFREE |
Ingenuity® Pathway Analysis Core Pathway and Network Analyses suggest a network by which miR-130b-3p, DENND1A, the luteinizing hormone/choriogonadotropin receptor, Ras-related protein 5B, and signaling pathways that they potentially target may mediate hyperandrogenism in PCOS.
|
31184707 |
2019 |
|
Polycystic Ovary Syndrome
|
0.200 |
Biomarker
|
disease |
BEFREE |
We demonstrate that Dennd1a, a susceptibility gene for PCOS, is essential for embryogenesis, probably through the mediation of endocytic recycling of selective cargos that are involved in cell signaling crucial for the development of multiple embryonic organ systems.
|
30884041 |
2019 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Minor allele frequency of rs10818854 and rs10986105 DENND1A variants were significantly higher among women with PCOS.
|
29325736 |
2018 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.
|
30566500 |
2018 |
|
Polycystic Ovary Syndrome
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Variant 2 of the DENND1A gene was found overexpressed in PCOS theca cells and confirmed to enhance androgen production.
|
26498719 |
2016 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, significant increase of PCOS risk was found between DENND1A-rs10818854 and PCOS susceptibility.
|
26757598 |
2016 |
|
Polycystic Ovary Syndrome
|
0.200 |
Biomarker
|
disease |
BEFREE |
PCOS has a strong genetic component, and genome-wide association studies have identified several candidate genes, notably DENND1A, which encodes connecdenn 1, involved in trafficking of endosomes.
|
27297658 |
2016 |
|
Polycystic Ovary Syndrome
|
0.200 |
Biomarker
|
disease |
BEFREE |
In addition, GWAS have suggested that DENND1A, epidermal growth factor signaling, and DNA repair pathways play a role in PCOS pathogenesis.
|
26908109 |
2016 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis.
|
27488699 |
2016 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To conclude we demonstrated lack of association of DENND1A SNPs rs10818854, rs2479106, and rs10986105, previously associated with PCOS in Asians, with PCOS in Bahraini Arab women.
|
25626177 |
2015 |
|
Polycystic Ovary Syndrome
|
0.200 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies based on adequate population samples have shown a higher frequency of genetic polymorphisms of the LHCGR, THADA and DENND1A genes in women with PCOS.
|
25835506 |
2015 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our previous research had identified three susceptibility loci (rs2479106, DENND1A; rs13405728, LHCGR; rs13429458, THADA) for PCOS in Han Chinese women.
|
25978310 |
2015 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variants in DENND1A (P = .0002), THADA (P = .035), FSHR (P = .007), and INSR (P = .046) were associated with PCOS in Europeans.
|
25303487 |
2015 |
|
Polycystic Ovary Syndrome
|
0.200 |
Biomarker
|
disease |
BEFREE |
Knock-down of DENND1A.V2 in PCOS theca cells reduced androgen biosynthesis and CYP17A1 and CYP11A1 gene transcription.
|
24706793 |
2014 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In a previous genome-wide association study, the SNP variants rs13429458, rs12478601, rs2479106, rs10818854 and rs13405728 in the THADA, DENND1A and LHCGR genes were identified as being independently associated with PCOS.
|
23208300 |
2013 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We therefore sequenced the DENND1A gene in white patients with PCOS to identify possible alterations that may be implicated in the PCOS pathogenesis.
|
24086769 |
2013 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variation in DENND1A was strongly associated with PCOS in the study cohort (p(combined cohorts)=10(-8)); multiple variants in THADA were also associated with PCOS, while there was no significant evidence for association of LHCGR variation with PCOS.
|
22180642 |
2012 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry.
|
22547425 |
2012 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
|
22885925 |
2012 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the polycystic ovary syndrome (PCOS) related single nucleotide polymorphisms (SNPs) rs13405728 (in gene LHCGR), rs13429458 (in gene THADA) and rs2479106 (in gene DENND1A) in women with endometrial carcinoma.
|
22902918 |
2012 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
|
22885925 |
2012 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
|
21151128 |
2011 |
|
Polycystic Ovary Syndrome
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
|
21151128 |
2011 |