NS2, Noonan syndrome 2, 57762

N. diseases: 9; N. variants: 0
Disease: Hepatitis C ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.060 Biomarker disease BEFREE HCV NS2 protein is a multifunctional regulator of HCV replication involved in both viral-genome replication and infectious-virus assembly. 31597774 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.060 GeneticVariation disease BEFREE The present study aimed to develop stable Gel.NPs conjugated with nonstructural protein 2 (NS2) gene of Hepatitis C Virus genotype 4a (HCV4a) as a safe and an efficient vaccine delivery system. 28746382 2017
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.060 GeneticVariation disease BEFREE The point of recombination was found to be within the HCV NS2 gene between nucleotide positions 3189-3200 based on H77 numbering. 28742818 2017
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.060 Biomarker disease BEFREE The HCV NS2 protein is a hydrophobic transmembrane protein that is associated with certain cellular proteins. 25625293 2015
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.060 Biomarker disease BEFREE Hepatitis C virus NS2 protein inhibits DNA damage pathway by sequestering p53 to the cytoplasm. 23638118 2013
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.060 Biomarker disease BEFREE The results showed that HCV NS2 protein up-regulated HCV IRES-dependent translation in a specific and dose-dependent manner in Huh7 cells but not in HeLa and HepG2 cells, and NS2 protein inhibited NS5B RdRp activity in a dose-independent manner in all three cell lines. 18853100 2008