NS2, Noonan syndrome 2, 57762
N. diseases: 9; N. variants: 0
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.090 | Biomarker | disease | BEFREE | The adaptive immune response is protective but wanes after each infection, likely due to the ability of the RSV NS1/NS2 proteins to inhibit the innate immune response. | 31284923 | 2019 |
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0.090 | GeneticVariation | disease | BEFREE | RSV/ΔNS2/Δ1313/I1314L contains 2 attenuating elements: (1) deletion of the interferon antagonist NS2 gene and (2) deletion of codon 1313 of the RSV polymerase gene and the stabilizing missense mutation I1314L. | 31605113 | 2019 |
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0.090 | GeneticVariation | disease | BEFREE | We generate a LAV candidate named OE4 which expresses line 19F and is attenuated by codon-deoptimization of non-structural (NS1 and NS2) genes, deletion of the small hydrophobic (SH) gene, codon-deoptimization of the attachment (G) gene and ablation of the secreted form of G. OE4 (RSV-A2-dNS1-dNS2-ΔSH-dG<sub>m</sub>-Gs<sub>null</sub>-line19F) exhibits elevated pre-fusion antigen levels, thermal stability, immunogenicity, and efficacy despite heavy attenuation in the upper and lower airways of cotton rats. | 28000669 | 2016 |
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0.090 | Biomarker | disease | BEFREE | Here, we discuss recent advances in understanding the interaction between RSV and the epithelium to induce pathogenesis in the airways, such as the role of the RSV NS2 protein in the airway epithelium, as well as the events involved in the RSV entry process. | 26119025 | 2016 |
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0.090 | Biomarker | disease | BEFREE | The NS2 protein is an effective target for prevention and treatment of RSV due to its antagonistic activity against the innate immune system. | 27147743 | 2016 |
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0.090 | GeneticVariation | disease | BEFREE | We combined the Δ1313 deletion with the previously described, attenuating NS2 gene deletion (ΔNS2) to produce the recombinant live-attenuated RSV vaccine candidate ΔNS2/Δ1313. | 23236065 | 2013 |
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0.090 | AlteredExpression | disease | BEFREE | Deletion of the NS1, but not NS2, protein resulted in three major effects: (i) an increased activation and proliferation of CD8+ T cells that express CD103, a tissue homing integrin that directs CD8+ T cells to mucosal epithelial cells of the respiratory tract and triggers cytolytic activity; (ii) an increased activation and proliferation of Th17 cells, which have recently been shown to have anti-viral effects and also indirectly attract neutrophils; and (iii) decreased activation of IL-4-producing CD4+ T cells--which are associated with enhanced RSV disease--and reduced proliferation of total CD4+ T cells. | 21533073 | 2011 |
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0.090 | Biomarker | disease | BEFREE | The NS2 protein of human respiratory syncytial virus suppresses the cytotoxic T-cell response as a consequence of suppressing the type I interferon response. | 16731934 | 2006 |
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0.090 | Biomarker | disease | BEFREE | Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]. | 15047850 | 2004 |