|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.090 |
Biomarker
|
disease |
BEFREE |
The adaptive immune response is protective but wanes after each infection, likely due to the ability of the RSV NS1/NS2 proteins to inhibit the innate immune response.
|
31284923 |
2019 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
RSV/ΔNS2/Δ1313/I1314L contains 2 attenuating elements: (1) deletion of the interferon antagonist NS2 gene and (2) deletion of codon 1313 of the RSV polymerase gene and the stabilizing missense mutation I1314L.
|
31605113 |
2019 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We generate a LAV candidate named OE4 which expresses line 19F and is attenuated by codon-deoptimization of non-structural (NS1 and NS2) genes, deletion of the small hydrophobic (SH) gene, codon-deoptimization of the attachment (G) gene and ablation of the secreted form of G. OE4 (RSV-A2-dNS1-dNS2-ΔSH-dG<sub>m</sub>-Gs<sub>null</sub>-line19F) exhibits elevated pre-fusion antigen levels, thermal stability, immunogenicity, and efficacy despite heavy attenuation in the upper and lower airways of cotton rats.
|
28000669 |
2016 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.090 |
Biomarker
|
disease |
BEFREE |
Here, we discuss recent advances in understanding the interaction between RSV and the epithelium to induce pathogenesis in the airways, such as the role of the RSV NS2 protein in the airway epithelium, as well as the events involved in the RSV entry process.
|
26119025 |
2016 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.090 |
Biomarker
|
disease |
BEFREE |
The NS2 protein is an effective target for prevention and treatment of RSV due to its antagonistic activity against the innate immune system.
|
27147743 |
2016 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We combined the Δ1313 deletion with the previously described, attenuating NS2 gene deletion (ΔNS2) to produce the recombinant live-attenuated RSV vaccine candidate ΔNS2/Δ1313.
|
23236065 |
2013 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Deletion of the NS1, but not NS2, protein resulted in three major effects: (i) an increased activation and proliferation of CD8+ T cells that express CD103, a tissue homing integrin that directs CD8+ T cells to mucosal epithelial cells of the respiratory tract and triggers cytolytic activity; (ii) an increased activation and proliferation of Th17 cells, which have recently been shown to have anti-viral effects and also indirectly attract neutrophils; and (iii) decreased activation of IL-4-producing CD4+ T cells--which are associated with enhanced RSV disease--and reduced proliferation of total CD4+ T cells.
|
21533073 |
2011 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.090 |
Biomarker
|
disease |
BEFREE |
The NS2 protein of human respiratory syncytial virus suppresses the cytotoxic T-cell response as a consequence of suppressing the type I interferon response.
|
16731934 |
2006 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.090 |
Biomarker
|
disease |
BEFREE |
Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected].
|
15047850 |
2004 |
|
Hepatitis C
|
0.060 |
Biomarker
|
disease |
BEFREE |
HCV NS2 protein is a multifunctional regulator of HCV replication involved in both viral-genome replication and infectious-virus assembly.
|
31597774 |
2019 |
|
Hepatitis C
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The present study aimed to develop stable Gel.NPs conjugated with nonstructural protein 2 (NS2) gene of Hepatitis C Virus genotype 4a (HCV4a) as a safe and an efficient vaccine delivery system.
|
28746382 |
2017 |
|
Hepatitis C
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The point of recombination was found to be within the HCV NS2 gene between nucleotide positions 3189-3200 based on H77 numbering.
|
28742818 |
2017 |
|
Hepatitis C
|
0.060 |
Biomarker
|
disease |
BEFREE |
The HCV NS2 protein is a hydrophobic transmembrane protein that is associated with certain cellular proteins.
|
25625293 |
2015 |
|
Hepatitis C
|
0.060 |
Biomarker
|
disease |
BEFREE |
Hepatitis C virus NS2 protein inhibits DNA damage pathway by sequestering p53 to the cytoplasm.
|
23638118 |
2013 |
|
Hepatitis C
|
0.060 |
Biomarker
|
disease |
BEFREE |
The results showed that HCV NS2 protein up-regulated HCV IRES-dependent translation in a specific and dose-dependent manner in Huh7 cells but not in HeLa and HepG2 cells, and NS2 protein inhibited NS5B RdRp activity in a dose-independent manner in all three cell lines.
|
18853100 |
2008 |
|
Influenza A
|
0.030 |
Biomarker
|
disease |
BEFREE |
Influenza A NS1 and NS2 proteins are encoded by the RNA segment 8 of the viral genome.
|
23853584 |
2013 |
|
Influenza A
|
0.030 |
Biomarker
|
disease |
BEFREE |
The non-structural protein 1 (NS1) of the influenza A virus and the NS2 protein, which is also known as nuclear export protein, play important roles in the infectious life cycle of the virus.
|
19420157 |
2009 |
|
Influenza A
|
0.030 |
Biomarker
|
disease |
BEFREE |
The most interesting new possibility for mimicry involving the P2 protein was between the influenza A NS2 protein and a sequence region of P2 thought to be neuritogenic in animals and mitogenic for lymphocytes from some patients with Guillain-Barré syndrome (GBS).
|
2458435 |
1988 |
|
Influenza
|
0.020 |
Biomarker
|
disease |
BEFREE |
The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication.
|
23853584 |
2013 |
|
Influenza
|
0.020 |
Biomarker
|
disease |
BEFREE |
We describe here the immunogenicity and protective capacity of replication-incompetent influenza virus-like particles (VLPs) which were generated entirely from cDNAs and lacked either the entire NS gene (encoding both the NS1 and NS2 protein) or only the NS2 gene.
|
11752166 |
2002 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Human papillomavirus type 16 E7 peptide-directed CD8+ T cells from patients with cervical cancer are cross-reactive with the coronavirus NS2 protein.
|
12692247 |
2003 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Human papillomavirus type 16 E7 peptide-directed CD8+ T cells from patients with cervical cancer are cross-reactive with the coronavirus NS2 protein.
|
12692247 |
2003 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Human papillomavirus type 16 E7 peptide-directed CD8+ T cells from patients with cervical cancer are cross-reactive with the coronavirus NS2 protein.
|
12692247 |
2003 |
|
Disease due to Parvoviridae
|
0.010 |
Biomarker
|
disease |
BEFREE |
NS-1 and NS-2 proteins may act synergistically in the cytopathogenicity of parvovirus MVMp.
|
2137660 |
1990 |
|
Guillain-Barre Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The most interesting new possibility for mimicry involving the P2 protein was between the influenza A NS2 protein and a sequence region of P2 thought to be neuritogenic in animals and mitogenic for lymphocytes from some patients with Guillain-Barré syndrome (GBS).
|
2458435 |
1988 |