|
Anemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Anaemia in TREX1 D18N mice is accompanied by increased erythropoietin (Epo), normal hepcidin levels and the TREX1 D18N mice display an inappropriate response to anaemic challenge.
|
30422000 |
2018 |
|
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Inappropriately low hepcidin levels cause iron overload, while increased hepcidin expression plays an important role in the anemia of inflammation (AI) by restricting intestinal iron absorption and macrophage iron release.
|
16946298 |
2007 |
|
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This case-control study aimed to study the levels of hepcidin and other proinflammatory markers (IL-6, TNF-α, hs-CRP) and their relation with anemia in iron- and erythropoietin-naïve, non-dialysis CKD (stage 3 - 5) patients.
|
29451472 |
2018 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Four variables were independently associated with postoperative kidney injury, for which the beta-coefficients (SE) were: minutes on cardiopulmonary bypass, 0.016 (0.004), p < 0.001; intra-operative hepcidin concentration, 0.032 (0.008), p < 0.001; pre-operative anaemia, 1.97 (0.56), p < 0.001; and Cleveland clinic risk score, 0.88 (0.35), p = 0.005.
|
29529338 |
2018 |
|
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
However, the regulatory mechanisms of hepcidin expression are multiple, including iron-related parameters, anemia, hypoxia, inflammation and hepatocyte function.
|
15974953 |
2005 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Baseline hepcidin measurement in the differential diagnosis of anaemia for elderly patients and its correlation with the increment of transferrin saturation following an oral iron absorption test.
|
30055098 |
2018 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Selenium deficiency has been linked to anemia of inflammation, which is mediated by hepcidin.
|
31597392 |
2019 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aims of the study were to determine if hepcidin is associated with severity of steady-state anemia in SCD and to investigate factors associated with hepcidin and anemia in SCD.
|
30056060 |
2018 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Hepcidin deficiency causes iron overload, whereas hepcidin excess causes or contributes to the development of iron-restricted anaemia in chronic inflammatory diseases.
|
28073521 |
2017 |
|
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
1) Background: Elevated hepcidin levels have been linked to anemia of inflammation (AI).
|
31052280 |
2019 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Ablation of hepcidin relieves iron restriction and improves the anemia.
|
24357728 |
2014 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Cytokine-mediated increases in hepcidin appear to be an important causative factor in anemia of inflammation, which is characterized by sequestration of iron in the macrophage system.
|
16627556 |
2006 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This work indicates that the crosstalk between liver hepcidin and intestinal HIF-2α plays an important role during iron overload, systemic iron deficiency, and anemia.
|
30530987 |
2019 |
|
Anemia
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
In EPO resistant anemia, multiple factors, including iron and inflammation related conditions, are likely to affect the level of hepcidin and this may explain the lack of elevated serum hepcidin in this condition.
|
18758412 |
2008 |
|
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Hepcidin expression is increased by higher body iron levels and inflammation and decreased by anemia and hypoxia.
|
22717199 |
2012 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Disturbances in the regulation of hepcidin contribute to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and nontransfused β-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic kidney disease, chronic inflammatory diseases, some cancers, and inherited iron-refractory iron deficiency anemia.
|
28096133 |
2017 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The model was able to simulate anemia when hepcidin was increased but was unable to simulate hemochromatosis when hepcidin was suppressed, suggesting that in high iron conditions additional regulatory interactions are important.
|
28521769 |
2017 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Elevated hepcidin concentrations are an important mediator of disordered iron metabolism, a key mechanism underlying anemia of CKD.
|
29426300 |
2018 |
|
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Hepcidin induction by RNAi-mediated inhibition of TMPRSS6 expression reduces iron overload and mitigates anemia in murine models of β-thalassemia intermedia.
|
29498084 |
2018 |
|
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Liver-specific overexpression of PGC-1α antagonizes lipopolysaccharide-induced HAMP expression and alleviates various pathophysiological changes similar to anemia of inflammation.
|
23438894 |
2013 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Hepcidin is also thought to play a vital role in the pathogenic mechanism of anaemia in patients with inflammation or chronic disease.
|
18054440 |
2008 |
|
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Both hepcidin and IL-1RN gene showed significant correlation with each other as well with RA disease activity parameters and anemia profile.
|
24014495 |
2013 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The linkage of hepcidin induction to inflammation in humans supports its proposed role as a key mediator of anemia of inflammation.
|
12433676 |
2003 |
|
Anemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In cooperation with the other pathways activated by inflammation, IL-1β pathway stimulation leads to excess production of hepcidin, which could be causative to anemia of inflammation.
|
28438835 |
2017 |
|
Anemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Knowledge of the regulation of hepcidin by inflammation, iron, erythropoiesis, and hypoxia will lead to an understanding of the pathogenesis of primary hemochromatosis, secondary iron overload, and anemia of inflammatory disease.
|
19400694 |
2009 |