|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, excessive hepcidin suppression contributes to iron overload in β-thalassemia.
|
31800957 |
2020 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Local hepcidin increased intracellular iron overload via the degradation of ferroportin in the kidney.
|
31761321 |
2020 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
The discovery of hepcidin and its role in iron homeostasis has revolutionized our understanding of the pathogenesis of iron deficiency and iron overload states.
|
31830663 |
2020 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, we suggest that using the ERFE gene expression, combined with serum hepcidin estimation, can substantiate the role of estimated TS% as a promising tool in screening for iron overload in β-TM patients.
|
31834456 |
2020 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate a molecular link between hepatic hepcidin and intestinal HIF-2α that controls physiological iron uptake and drives iron hyperabsorption during iron overload.
|
30352047 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
By suppressing hepcidin, ERFE facilitates iron delivery during stress erythropoiesis but also contributes to iron overload in anemias with ineffective erythropoiesis.
|
29981834 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Iron overload stimulated hepcidin synthesis, while IR had an inhibitory effect and even inhibited the stimulatory effects of iron overload.
|
31691189 |
2019 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Alterations in hepcidin levels are associated with restricted erythropoiesis, anemia, and iron overload.
|
31477260 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hepcidin an acute phase peptide hormone gets elevated in conditions of iron overload, inflammation, infections, and cytotoxicity.
|
31736392 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hemochromatoses, mostly but not exclusively related to the HFE gene, correspond to systemic iron overload of genetic origin in which iron excess is the consequence of hepcidin deficiency, hepcidin being the hormone regulating negatively plasma iron.
|
30173950 |
2019 |
|
Iron Overload
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Nerve growth factor-beta (NGF-β)-differentiated PC12 cells, used as a model of neuronal cells, were evaluated in terms of their viability and expression of ferroportin after inducing cellular iron overload with ferric ammonium citrate (FAC) or hepcidin, iron deficiency with deferoxamine (DFO), or hepcidin in combination with FAC or DFO.
|
30027341 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
CONCLUSIONS Qizhufang (ZSF) can ameliorate iron overload-induced injury by suppressing hepcidin via the STAT3 pathway in LO2 cells.
|
31628297 |
2019 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Pharmacologic targeting of BMP-SMAD pathway components or regulators may improve the outcome of both genetic and acquired disorders of iron overload and deficiency by increasing or inhibiting hepcidin expression.
|
30798817 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
The paradigm is non-transfusion-dependent thalassemia where the release of erythroferrone from the expanded pool of immature erythroid cells results in hepcidin suppression and secondary iron overload that in turn worsens ineffective erythropoiesis and anemia.
|
31649559 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Bitopertin also upregulates liver hepcidin and diminishes liver iron overload.
|
31593554 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated that systemic Hepc knockout (HepcKO) mice, which have high serum iron, develop retinal iron overload and degeneration.
|
31287995 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
The primary etiology of iron overload in these diseases is insufficient production of hepcidin by the liver, leading to excessive intestinal iron absorption and iron efflux from macrophages.
|
30792208 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Full repression of hepcidin was observed in BALB/c and 129/Sv mice, favoring parenchymal iron overload in the liver.
|
31601421 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Dysregulation of hepcidin production contributes to the pathogenesis of many iron disorders: hepcidin deficiency causes iron overload in hereditary hemochromatosis and non-transfused β-thalassemia, whereas overproduction of hepcidin is associated with iron-restricted anemias seen in patients with chronic inflammatory diseases and inherited iron-refractory iron-deficiency anemia.
|
30798807 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
The inability to appropriately regulate hepcidin production in response to these physiologic cues underlies genetic disorders of iron overload and deficiency, including hereditary hemochromatosis and iron-refractory iron deficiency anemia.
|
30401708 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
Considering the actual alerts about risk of iron overload in dialysis patients, inhibition of hepcidin, the central key player in iron homeostasis, could be a pivotal strategy in the management of CKD anemia.
|
30798815 |
2019 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our study showed that green tea extract (GTE) ameliorates iron overload induced hepatotoxicity, apoptosis and oxidative stress in rat liver via inhibition of hepatic iron accumulation; improve of liver antioxidant capacity, and down regulation of serum hepcidin as well as reduction in the release of apoptotic relating proteins.
|
30899168 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
In diseases with abnormal hepcidin levels, including chronic inflammation, special attention should be paid to those metals that can participate with the phenotype.-Cavey, T., Latour, C., Island, M.-L., Leroyer, P., Guggenbuhl, P., Coppin, H., Roth, M.-P., Bendavid, C., Brissot, P., Ropert, M., Loréal, O. Spleen iron, molybdenum, and manganese concentrations are coregulated in hepcidin-deficient and secondary iron overload models in mice.
|
31298936 |
2019 |
|
Iron Overload
|
0.600 |
Biomarker
|
disease |
BEFREE |
This work indicates that the crosstalk between liver hepcidin and intestinal HIF-2α plays an important role during iron overload, systemic iron deficiency, and anemia.
|
30530987 |
2019 |
|
Iron Overload
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The hepcidin levels were more strongly related to ineffective erythropoiesis compared with iron overload.
|
30745811 |
2019 |