HAMP, hepcidin antimicrobial peptide, 57817

N. diseases: 377; N. variants: 15
Disease: Iron Overload ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Iron overload was mediated by decreased hepatic expression of hepcidin, a key regulator of iron homeostasis. 27903529 2017
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Iron overload [serum ferritin (SF) ≥ 1500 ng/ml] was independently associated with TM (p = 0.001) and elevated serum hepcidin (p = 0.02). 28600663 2017
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Iron overload (IOL) starts to develop in MDS patients before they become transfusion-dependent because ineffective erythropoiesis suppresses hepcidin production in the liver and thus leads to unrestrained intestinal iron uptake. 29177643 2018
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Iron overload has been associated with oxidative stress, advanced fibrosis and decreased survival, and promising therapies beyond phlebotomy and oral iron chelation have included hepcidin agonists. 30761559 2019
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Iron overload in congenital haemolytic anaemias: role of hepcidin and cytokines and predictive value of ferritin and transferrin saturation. 30828802 2019
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Iron overload stimulated hepcidin synthesis, while IR had an inhibitory effect and even inhibited the stimulatory effects of iron overload. 31691189 2019
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin is a hepatic antimicrobial-like peptide whose role in iron homeostasis was first defined in animal models; deficiency of hepcidin in mice leads to iron overload, whereas its hepatic overexpression in transgenic animals causes iron deficiency. 14630809 2004
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 GeneticVariation disease BEFREE HAMP gene mutations have been described to date in five families with iron overload. 15024747 2004
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin is considered to constitute a negative regulator of iron absorption, and its production is increased in inflammatory states and iron overload. 15198949 2004
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Hepcidin is the presumed negative regulator of systemic iron levels; its expression is induced in iron overload, infection, and inflammation, and by cytokines, but is suppressed in hypoxia and anemia. 16902156 2006
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin production is increased by iron overload and decreased by anemia and hypoxia; but the molecular mechanisms that govern the hepcidin response to these stimuli are not known. 17557118 2007
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin deficiency causes common iron overload syndromes whereas its overexpression is responsible for microcytic anemias. 20040761 2010
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin, the central regulator of iron homeostasis, is deficient in HH, leading to unchecked iron absorption and subsequent iron overload. 20658468 2010
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin response to acute iron intake and chronic iron loading in dysmetabolic iron overload syndrome. 21733088 2011
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin deficiency underlies iron overload in HFE-hemochromatosis as well as in several other genetic iron excess disorders, such as hemojuvelin or hepcidin-related hemochromatosis and transferrin receptor 2-related hemochromatosis. 21862411 2011
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin deficiency causes iron overload in hereditary hemochromatosis and ineffective erythropoiesis. 22306005 2012
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Hepcidin insufficiency and increased iron absorption are also characteristic of anemia due to ineffective erythropoiesis in which, despite high total body iron, hepcidin is suppressed by the high erythropoietic activity, worsening both iron overload and anemia in a vicious cycle. 24319154 2013
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin deficiency causes iron overload, whereas hepcidin excess causes or contributes to the development of iron-restricted anaemia in chronic inflammatory diseases. 28073521 2017
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin is a 25-amino acid peptide produced by the liver in response to inflammation and iron overload. 28530443 2017
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Hepcidin is a key iron regulatory hormone that controls expression of the iron exporter ferroportin to increase the iron supply when needed to support erythropoiesis and other essential functions, but to prevent the toxicity of iron excess. 28815688 2017
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Hepcidin induction by RNAi-mediated inhibition of TMPRSS6 expression reduces iron overload and mitigates anemia in murine models of β-thalassemia intermedia. 29498084 2018
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin agonists also have the potential to prevent severe complications of siderophilic infections in patients with iron overload or chronic liver disease. 29523504 2018
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin is the master regulator of iron homeostasis in vertebrates, responsible for diminishing iron export from macrophages during iron overload or infection. 29764842 2018
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 AlteredExpression disease BEFREE Hepcidin, a liver-derived hormone, negatively regulates circulating iron levels through an increase in its expression in response to iron overload. 30269025 2018
CUI: C0282193
Disease: Iron Overload
Iron Overload 		0.600 Biomarker disease BEFREE Hepcidin an acute phase peptide hormone gets elevated in conditions of iron overload, inflammation, infections, and cytotoxicity. 31736392 2019