|
Liver diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The hepcidin response to higher body iron levels and/or inflammation appeared to be functional in these patients, despite the presence of liver disease.
|
31835128 |
2020 |
|
Liver diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data suggest differences driven by hepcidin and IL-6 expression between CCl4 and TAA liver fibrosis models and are of clinical importance for diagnosis and therapeutics of liver diseases.
|
30987689 |
2019 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This article highlights the potential therapeutic benefit of exogenous hepcidin to prevent and treat iron-induced injury, specifically in the management of infection from enteric gram-negative bacilli or fungi, malaria, sepsis, acute kidney injury, trauma, transfusion, cardiopulmonary bypass surgery, and liver disease.
|
30784615 |
2019 |
|
Liver diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
An inappropriately low serum hepcidin level has characterised most chronic liver diseases with the exception of non-alcoholic fatty liver disease, and the finding has been associated mainly with suppression of transcriptional activity of the hepcidin gene.
|
30761559 |
2019 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The discussion also expands on clinical studies that suggest that hepcidin can potentially be used as a biochemical parameter of fibrosis/cirrhosis and target of therapeutic strategies to treat liver diseases.
|
30134796 |
2018 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Serum hepcidin was increased similarly in NAFLD with DIOS as in the other chronic liver diseases with iron overload, except for genetic hemochromatosis.
|
29871592 |
2018 |
|
Liver diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.
|
26310624 |
2015 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In summary, parallel determination of liver hepcidin mRNA and serum hepcidin in patients with chronic liver diseases shows that circulating hepcidin and its respective ratio to ferritin are significantly diminished in patients with autoimmune liver diseases.
|
26270641 |
2015 |
|
Liver diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The differences in iron metabolism between the two widely used fibrosis models likely reflect the differential regulation of hepcidin expression in human liver disease.
|
23749468 |
2013 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated the potential role of serum hepcidin as a biomarker of advanced liver disease.
|
22676252 |
2012 |
|
Liver diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
EGF, HGF, and possibly other growth factors that activate similar pathways may contribute to hepcidin suppression in chronic liver diseases, promote iron accumulation in the liver, and exacerbate the destructive disease processes.
|
22278715 |
2012 |
|
Liver diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, hepcidin expression levels in chronic liver diseases were strongly correlated with either the serum ferritin concentration or degree of iron deposits in the liver.
|
17515961 |
2007 |