|
Thalassemia
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mean (SD) serum hepcidin levels in 40 children with thalassemia [15.8 (2.9) ng/mL] were comparable to those seen in 40 healthy controls [15.1 (3.0) ng/mL (P=0.3)].
|
29941702 |
2018 |
|
Thalassemia
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Diminished β-globin synthesis in β-thalassemia is associated with ineffective erythropoiesis, leading to secondary iron overload caused by inappropriately low levels of hepcidin and to splenomegaly in the symptomatic thalassemias.
|
29498084 |
2018 |
|
Thalassemia
|
0.100 |
Biomarker
|
group |
BEFREE |
The determination of soluble hemojuvelin (sHJV) levels could allow for a better understanding of the pathophysiological mechanisms of hepcidin regulation in thalassaemia.
|
27440164 |
2017 |
|
Thalassemia
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Suppression of hepcidin expression occurs physiologically in iron deficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis.
|
28864822 |
2017 |
|
Thalassemia
|
0.100 |
Biomarker
|
group |
BEFREE |
The effect of thalassemia carriage on hepcidin is also unknown, but it could be relevant for iron supplementation programs aimed at combating anemia.
|
25519750 |
2015 |
|
Thalassemia
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, the correlation of hepcidin level with some endocrine and biochemical parameters was investigated to determine the factors that mainly affect hepcidin correlation in patients with thalassemia.
|
25923089 |
2015 |
|
Thalassemia
|
0.100 |
Biomarker
|
group |
BEFREE |
The index sTfR/log ferritin and (hepcidin/ferritin)/sTfR are, respectively, increased and reduced relative to controls, proportional to the severity of each thalassemia group.
|
25307880 |
2015 |
|
Thalassemia
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Monocyte HAMP mRNA content of patients with thalassemia correlated with plasma IL-6 and CRP levels.
|
23905873 |
2014 |
|
Thalassemia
|
0.100 |
Biomarker
|
group |
BEFREE |
Hepcidin manipulation to restrict iron is a successful strategy to improve erythropoiesis in thalassemia, as shown clearly in preclinical studies targeting TMPRSS6; attempts to control anemia of chronic diseases by antagonizing the hepcidin effect are ongoing.
|
24319154 |
2013 |
|
Thalassemia
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our aims were: a. to measure hepcidin expression at either hepatic, serum and urinary level in three paradigmatic iron overload conditions (hemochromatosis, thalassemia and dysmetabolic iron overload syndrome) and in controls; b. to measure mRNA hepcidin expression in two different hepatic cell lines (HepG2 and Huh-7) exposed to patients and controls sera to assess whether circulating factors could influence hepcidin transcription in different pathological conditions.
|
22586470 |
2012 |
|
Thalassemia
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Previously, it was reported that the erythrokine GDF15 is expressed at very high levels in thalassemia and suppresses hepcidin expression.
|
19414861 |
2009 |
|
Thalassemia
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.
|
17721544 |
2007 |
|
Thalassemia
|
0.100 |
Biomarker
|
group |
BEFREE |
In the future, hepcidin measurements may allow a more accurate assessment of the degree of iron overload and the maldistribution of iron in thalassemia.
|
17488680 |
2007 |
|
Thalassemia
|
0.100 |
Biomarker
|
group |
LHGDN |
Urinary hepcidin levels in beta-thalassemia demonstrate severe hepcidin deficiency in thalassemia intermedia.
|
17488680 |
2007 |
|
Thalassemia
|
0.100 |
AlteredExpression
|
group |
LHGDN |
These results suggest that GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.
|
17721544 |
2007 |
|
Thalassemia
|
0.100 |
Biomarker
|
group |
LHGDN |
We conclude that hepcidin expression is regulated mainly by increased erythropoietic activity rather than by iron load and that hepcidin plays a central regulatory role in iron circulation and iron toxicity in patients with thalassemia.
|
16769583 |
2006 |
|
Thalassemia
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Significant down-regulation of hepcidin expression in beta-thalassemia major, despite iron overload, might explain the increased iron absorption typically observed in thalassemia.
|
16755567 |
2006 |
|
Thalassemia
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that hepcidin expression is regulated mainly by increased erythropoietic activity rather than by iron load and that hepcidin plays a central regulatory role in iron circulation and iron toxicity in patients with thalassemia.
|
16769583 |
2006 |
|
Thalassemia
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is secreted into the bloodstream.
|
16339690 |
2005 |